Influence of acute dietary nitrate supplementation on oxygen delivery/consumption and limit of tolerance during progressive forearm exercise in men: a randomized crossover trial
Fenuta AM, Drouin PJ, Kohoko ZIN, Lynn MJT, Tschakovsky ME
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ontario Innovation Trust
- Universidad u hospital
- School of Graduate Studies - Queen’s University
- Gobierno
- Canadian Foundation for Innovation
- Gobierno
- NSERC Discovery Grant
- Sin clasificar
- Research Tools and Instruments
Según 5 financiadores declarados.
Publicación
- Publicado
- 2024-01-08 · Appl Physiol Nutr Metab · vol. 49 · número 5 · págs. 635–648
- Editorial
- NRC Research Press
- Citado
- 1 cita · más que el 60% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 73 trabajos
- Acceso
- De pago
- Áreas de investigación
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Palabras clave
- beetroot juice, dietary nitrate, nitric oxide bioavailability, oxygen delivery, oxygen consumption, arteriovenous oxygen difference, forearm blood flow, vascular conductance, high-intensity exercise, vasodilation
- MeSH
- forearm, humans, beta vulgaris, nitrates, oxygen, exercise test, exercise, cross-over studies, oxygen consumption, exercise tolerance, dietary supplements, adult, male, young adult, fruit and vegetable juices
5 autores
- Alyssa M. Fenuta🇨🇦Queen's University
- Patrick J. Drouin🇨🇦Queen's University
- Zach I.N. Kohoko🇨🇦Queen's University
- Mytchel J.T. Lynn🇨🇦Queen's University
- Michael E. Tschakovsky🇨🇦Queen's University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Beetroot juice (BRJ) supplementation increases nitric oxide bioavailability with hypoxia and acidosis, characteristics of high-intensity exercise. We investigated whether BRJ improved forearm oxygen delivery:demand matching in an intensity-dependent manner. Healthy men (21 ± 2.5 years) participated in a randomized crossover trial between October 2017 and May 2018 (Queen's University, Kingston, ON, Canada). Participants completed a forearm incremental exercise test to limit of tolerance (IET-LOT) 2.5 h post placebo (PL) versus BRJ (2 completed PL/BRJ vs. 9 completed BRJ/PL) within a 2-week period. Data are presented as mean ± standard deviation. There was a significant main effect of drink (PL P = 0.042, ηp2 = 0.385) and drink × intensity interaction for arteriovenous oxygen difference (PL P = 0.03; ηp2= 0.197; 20%-50% and 90% LOT). BRJ did not influence oxygen delivery (P = 0.893, ηp2 = 0.002), forearm blood flow (P = 0.589, ηp2 = 0.03) (forearm vascular conductance (P = 0.262, ηp2 = 0.124), mean arterial pressure (P = 0.254,ηp2 = 0.128)), oxygen consumption (P = 0.194, ηp2 = 0.179) or LOT (P = 0.432, d = 0.247). In healthy men, BRJ did not improve forearm oxygen delivery (vasodilatory or pressor response) during IET-LOT. Increased arteriovenous oxygen difference at submaximal intensities did not significantly influence oxygen consumption or performance across the entire range of forearm exercise intensities. This study adds to the growing body of evidence that BRJ does not influence small muscle mass blood flow in humans regardless of exercise intensity.
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