The Effects of Repeated Low-Level Red-Light Therapy on the Structure and Vasculature of the Choroid and Retina in Children with Premyopia
Liu Z, Sun Z, Du B, Gou H, Wang B, Lin Z, Ren N, Pazo EE, Liu L, Wei R
Ophthalmology and therapy · 43 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Subvenciones
- National Natural Science Foundation of China (82070929.)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-01-10 · Ophthalmol Ther · vol. 13 · número 3 · págs. 739–759
- Editorial
- Adis, Springer Healthcare
- Citado
- 46 citas · más que el 99% de estudios similares · 12.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Retinal Diseases and Treatments
- Palabras clave
- Medicine, Foveal, Ophthalmology, Choroid, Retinal, Retina, Optical coherence tomography, Perfusion, Fluorescein angiography, Nuclear medicine, Cardiology, Optics
10 autores
- Zhuzhu Liu🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Ziwen Sun🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Bei Du🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Huaixue Gou🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Biying Wang🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Zeya Lin🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Nuo Ren🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Emmanuel Eric Pazo🇨🇳Tianjin Medical University Eye Hospital; Tianjin Medical University
- Lin Liu🇨🇳 · autor de correspondenciaTianjin Medical University Eye Hospital; Tianjin Medical University
- Ruihua Wei🇨🇳 · autor de correspondenciaTianjin Medical University Eye Hospital; Tianjin Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
The purpose of this study was to explore the effects of repeated low-level red-light (RLRL) therapy on the structure and vasculature of the choroid and retina in Chinese children with premyopia.
Methods
This study was a single-center randomized clinical trial. A total of 94 children with premyopia (- 0.50 D < spherical equivalent [SE] ≤ + 0.75 D) were randomly assigned to either the RLRL therapy or control group. Follow-up visits were planned at 1, 3, 6, 9, and 12 months. Optical coherence biometry was used to measure axial length (AL) and anterior segment parameters. Choroidal thickness (CT), retinal thickness (RT), superficial retinal vascular density (SRVD), deep retinal vascular density (DRVD), choriocapillaris perfusion area (CCPA), and choroidal vessel volume (CVV) were measured by optical coherence tomography angiography, centered on the foveal, parafoveal (ParaF), and perifoveal (PeriF) regions.
Results
The thickening of the choroid was observed across the entire macular region at different time points in the RLRL therapy group. Relative to the baseline measurement, foveal CT significantly increased at the 1-month follow-up with RLRL therapy, with a mean (± standard deviation [SD]) adjusted change of 16.96 ± 19.87 μm. The greatest magnitude of foveal CT changes was observed at the 3-month visit (an increase of 19.58 ± 20.59 μm), with a slight reduction in the extent of foveal CT increase at the 6-month visit (an increase of 15.85 ± 23.77 μm). The second greatest CT increase was observed at the 9-month visit (an increase of 19.57 ± 35.51 μm), after which the extent of CT increase gradually decreased until the end of the study at the 12-month visit (an increase of 11.99 ± 32.66 μm). We also observed a significant increase in CT in the ParaF and PeriF areas in the RLRL group over 12 months. In contrast, CT across the entire macular region in the control group significantly decreased throughout the follow-up visits (all P 2), 3-month (an increase of 0.25 mm2), and 12-month visits (an increase of 0.42 mm2) (all P 0.05). Notably, RLRL therapy achieved a notable reduction in SE shift by 73.8%, a substantial decrease in AL change by 67.9%, and a significant reduction in myopia incidence by 45.1% within 1 year.
Conclusion
Our study demonstrated a significant increase in CT and flow in the RLRL-treated eyes throughout the 12-months of the study. Combined with its reduction in spherical equivalent progression and axial elongation, RLRL could be used as an effective therapy for preventing progression in premyopes.
Trial registration
ChiCTR2200062028.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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