Effect of walnut consumption on markers of endothelial function in adults: A systematic review and meta-analysis of randomized controlled trials
Hsu CY, Hsu CY, Alzahrani AA, Maabreh HG, Prasad KDV, Bokov DO, Kareem AH, Alawadi A, Ihsan A, Shakir MN, Alasheqi MQ
Phytotherapy research : PTR · 5 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-01-10 · Phytother Res · vol. 38 · número 3 · págs. 1358–1366
- Editorial
- Wiley
- Citado
- 7 citas · más que el 61% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects
- Palabras clave
- Meta-analysis, Medicine, Randomized controlled trial, Strictly standardized mean difference, Internal medicine, Web of science, MEDLINE, Gastroenterology, Biology, Biochemistry
- MeSH
- humans, juglans, nuts, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, adult, randomized controlled trials as topic
10 autores
- Chou‐Yi Hsu🇹🇼Chia Nan University of Pharmacy and Science
- Abdullah Ali Alzahrani🇸🇦 · autor de correspondenciaTaif University
- Hatem Ghaleb Maabreh🇷🇺Peoples' Friendship University of Russia
- KDV Prasad🇮🇳Symbiosis International University
- Dmitry Olegovich Bokov🇷🇺Sechenov University; Federal Research Centre of Nutrition and Biotechnology; All-Russian Scientific Research Institute of Food Biotechnology
- Anaheed Hussein Kareem🇮🇶Al-Ayen Iraqi University
- Ahmed Hussien Alawadi🇮🇶University of Babylon; Iraqi University
- Ihsan Ali🇮🇷Imam Sadiq University; Imam Ja’afar Al-Sadiq University
- Maha Noori Shakir🇮🇶Al-Nisour University College
- Mohammed Qasim Alasheqi🇮🇶National University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Findings on the effect of walnut consumption on endothelial function are conflicting. Therefore, the present systematic review and meta-analysis summarized available trials in this regard. A systematic search was performed in online databases including PubMed-Medline, Scopus, and ISI Web of Science up to October 2023. Articles that reported the effect of walnut intake on flow-mediated dilation (FMD), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and stimulus-adjusted response measure (SARM) were included. Random effects models for a weighted mean difference (WMD) or standardized mean difference (SMD) were used to test for the overall effect. Six eligible trials were analyzed (250 participants). Walnut intake significantly increased FMD (WMD: 0.94%, 95% CI: 0.12 to 1.75; p = 0.02). However, meta-analysis could not show any beneficial effect of walnut intake on ICAM-1 (SMD: -0.23, 95% CI: -0.68 to 0.22; p = 0.31), VCAM-1 (SMD: -0.02, 95% CI: -1.38 to 1.34; p = 0.97), and SARM (WMD: 0.01%, 95% CI: -0.01 to 0.04; p = 0.28). In conclusion, the present meta-analysis suggests that walnuts may reduce cardiovascular disease risk by improving FMD. However, further studies should be performed on adults to determine the effect of walnut intake on endothelial function.
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