Hypohydration attenuates increases in creatinine clearance to oral protein loading and the renal hemodynamic response to exercise pressor reflex
Chapman CL, Holt SM, O'Connell CT, Brazelton SC, Medved HN, Howells WAB, Reed EL, Needham KW, Halliwill JR, Minson CT
Journal of applied physiology (Bethesda, Md. : 1985) · 8 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Oregon
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Gobierno
- HHS | NIH | National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NICHD NIH HHS
- Gobierno
- HHS | National Institutes of Health
- Subvenciones
- National Heart, Lung, and Blood Institute (R01 HL144128); National Heart, Lung, and Blood Institute (F32 HL164021); Eunice Kennedy Shriver National Institute of Child Health and Human Development (R25HD070817); National Institutes of Health (R25HD070817)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2024-01-11 · J Appl Physiol (1985) · vol. 136 · número 3 · págs. 492–508
- Editorial
- American Physiological Society
- Citado
- 7 citas · más que el 82% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 86 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Thermoregulation and physiological responses · Heart Rate Variability and Autonomic Control · High Altitude and Hypoxia
- Palabras clave
- Reflex, Medicine, Creatinine, Hemodynamics, Endocrinology, Internal medicine, Renal function, Vascular resistance, Urine, Haemodynamic response, Blood pressure, Heart rate
- MeSH
- humans, water, creatinine, reflex, hand strength, female, male, hemodynamics, young adult
10 autores
- Christopher L. Chapman🇺🇸University of Oregon
- Sadie M. Holt🇺🇸University of Oregon
- Cameron T. O’Connell🇺🇸University of Oregon
- Shaun C. Brazelton🇺🇸University of Oregon
- Hannah N. Medved🇺🇸University of Oregon
- William A. B. Howells🇺🇸University of Oregon
- Emma L. Reed🇺🇸University of Oregon
- Karen Wiedenfeld Needham🇺🇸University of Oregon
- John R. Halliwill🇺🇸University of Oregon
- Christopher Todd Minson🇺🇸 · autor de correspondenciaUniversity of Oregon
Resumen
El texto original del estudio, en el idioma en que se publicó.
Insufficient hydration is prevalent among free living adults. This study investigated whether hypohydration alters 1) renal functional reserve, 2) the renal hemodynamic response to the exercise pressor reflex, and 3) urine-concentrating ability during oral protein loading. In a block-randomized crossover design, 22 healthy young adults (11 females and 11 males) underwent 24-h fluid deprivation (Hypohydrated) or 24-h normal fluid consumption (Euhydrated). Renal functional reserve was assessed by oral protein loading. Renal hemodynamics during the exercise pressor reflex were assessed via Doppler ultrasound. Urine-concentrating ability was assessed via free water clearance. Creatinine clearance did not differ at 150 min postprotein consumption between conditions [Hypohydrated: 246 mL/min, 95% confidence interval (CI): 212-280; Euhydrated: 231 mL/min, 95% CI: 196-265, P = 0.2691] despite an elevated baseline in Hypohydrated (261 mL/min, 95% CI: 218-303 vs. 143 mL/min, 95% CI: 118-168, P P = 0.9290), but increases were attenuated in Hypohydrated versus Euhydrated at the end of handgrip (0.5 mmHg/cm/s, 95% CI: 0.4-0.7 vs. 0.8 mmHg/cm/s 95% CI: 0.6-1.1, P = 0.0203) and end occlusion (0.2 mmHg/cm/s, 95% CI: 0.1-0.3 vs. 0.4 mmHg/cm/s 95% CI: 0.3-0.6, P = 0.0127). There were no differences between conditions in free water clearance at 150 min postprotein (P = 0.3489). These data indicate that hypohydration 1) engages renal functional reserve and attenuates the ability to further increase creatinine clearance, 2) attenuates increases in renal artery vascular resistance to the exercise pressor reflex, and 3) does not further enhance nor impair urine-concentrating ability during oral protein loading.NEW & NOTEWORTHY Insufficient hydration is prevalent among free living adults. This study found that hypohydration induced by 24-h fluid deprivation engaged renal functional reserve and that oral protein loading did not further increase creatinine clearance. Hypohydration also attenuated the ability to increase renal vascular resistance during the exercise pressor reflex. In addition, hypohydration neither enhanced nor impaired urine-concentrating ability during oral protein loading. These data support the importance of mitigating hypohydration in free living adults.
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