Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trials
Moabedi M, Aliakbari M, Erfanian S, Milajerdi A
Frontiers in psychiatry · 18 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-12-22 · Front Psychiatry · vol. 14 · pág. 1333261
- Editorial
- Frontiers Media
- Citado
- 30 citas · más que el 87% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Heavy Metal Exposure and Toxicity · Bipolar Disorder and Treatment
- Palabras clave
- Meta-analysis, Randomized controlled trial, Depression (economics), Placebo, Medicine, Strictly standardized mean difference, Clinical trial, Sample size determination, Internal medicine, Systematic review, Depressive symptoms, Major depressive disorder, MEDLINE, Psychiatry, Physical therapy, Anxiety, Alternative medicine, Pathology
4 autores
- Mahdi Moabedi🇮🇷Kashan University of Medical Sciences
- Mohammadreza Aliakbari🇮🇷Kashan University of Medical Sciences
- Shima Erfanian🇮🇷Isfahan University of Medical Sciences
- Alireza Milajerdi🇮🇷 · autor de correspondenciaKashan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The findings from randomized clinical trials (RCTs) examining the effect of magnesium supplementation on depression are inconsistent. We decided to conduct a meta-analysis that summarizes all the evidence on the impact of magnesium supplementation on depression scores in adults with depressive disorder.
Methods
We conducted a systematic search in the online databases using all related keywords up to July 2023. We included all randomized clinical trials examining the effect of magnesium, in contrast to placebo, on depression scores.
Results
Finally, seven clinical trials were included in this systematic review, building up a total sample size of 325 individuals with ages ranging from 20 to 60 years on average. These RCTs resulted in eight effect sizes. Our findings from the meta-analysis showed a significant decline in depression scores due to intervention with magnesium supplements [standardized mean difference (SMD): -0.919, 95% CI: -1.443 to -0.396, p = 0.001].
Conclusion
Our review suggests that magnesium supplementation can have a beneficial effect on depression. Future high-quality RCTs with larger sample sizes must be run to interpret this effect of magnesium on depression in clinical settings.
Systematic review registration
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=447909.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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