Effects of time-restricted eating on intrahepatic fat and metabolic health among patients with nonalcoholic fatty liver disease
Deng Y, Liu X, Sun Y, Zhou L, Li Q, Lei Z, Yang F, Chen L, Zhang C, Tan W, Jin X, Han Z, Xu H, Wang Q, Nie Q, Yi H, Bao W, Rong S
Obesity (Silver Spring, Md.) · 15 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Wuhan University
- Universidad u hospital
- Wuhan University of Science and Technology
- Subvenciones
- National Natural Science Foundation of China (82073552); National Natural Science Foundation of China (82373575); National Natural Science Foundation of China (82204038)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2024-01-16 · Obesity (Silver Spring) · vol. 32 · número 3 · págs. 494–505
- Editorial
- Wiley
- Citado
- 22 citas · más que el 96% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Dietary Effects on Health · Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease
- Palabras clave
- Nonalcoholic fatty liver disease, Medicine, Internal medicine, Fatty liver, Gastroenterology, Liver function, Randomization, Randomized controlled trial, Obesity, Endocrinology, Disease
- MeSH
- liver, humans, magnetic resonance imaging, body composition, adult, non-alcoholic fatty liver disease
18 autores
- Yan Deng🇨🇳Wuhan University of Science and Technology
- Xiaoming Liu🇭🇰🇨🇳Union Hospital; Wuhan Union Hospital; Huazhong University of Science and Technology
- Yuzhe Sun🇨🇳BGI Group (China); Beijing Graphene Institute; BGI Research
- Li Zhou🇨🇳Wuhan University of Science and Technology
- Qiang Li🇭🇰🇨🇳Union Hospital; Wuhan Union Hospital; Huazhong University of Science and Technology
- Ziqiao Lei🇭🇰🇨🇳Union Hospital; Wuhan Union Hospital; Huazhong University of Science and Technology
- Fan Yang🇭🇰🇨🇳Union Hospital; Wuhan Union Hospital; Huazhong University of Science and Technology
- Liangkai Chen🇨🇳Huazhong University of Science and Technology
- Chen Zhang🇭🇰🇨🇳Union Hospital; Wuhan Union Hospital; Union Hospital; Huazhong University of Science and Technology
- Wei Tan🇨🇳Wuhan University of Science and Technology
- Xin Jin🇨🇳Wuhan University of Science and Technology
- Zhuang Han🇨🇳Wuhan University of Science and Technology
- Huiyang Xu🇨🇳Wuhan University of Science and Technology
- Qing Wang🇨🇳Wuhan University of Science and Technology
- Qi Nie🇨🇳Wuhan University of Science and Technology
- Haoran Yi🇨🇳Wuhan University of Science and Technology
- Wei Bao🇨🇳University of Science and Technology of China
- Shuang Rong🇨🇳 · autor de correspondenciaWuhan University; Wuhan University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The study's objective was to explore whether early time-restricted eating (eTRE) and late time-restricted eating (lTRE) have different impacts on intrahepatic fat and metabolic health among patients with nonalcoholic fatty liver disease (NAFLD).
Methods
This is an 8-week, randomized, parallel-arm, open-label trial. Forty eligible patients were randomly assigned to eTRE (eating between 8:00 a.m. and 4:00 p.m.) or lTRE (eating between 12:00 p.m. and 8:00 p.m.). The primary outcome was the change of intrahepatic fat measured by magnetic resonance image-derived proton density fat fraction. Secondary outcomes included changes in weight, body composition, liver function, and cardiometabolic factors.
Results
Forty participants who underwent randomization completed the trial (mean age: 38.25 years). The eTRE group had a -3.24% absolute reduction of intrahepatic fat (95% CI: -4.55% to -1.92%) and there was a -3.51% absolute reduction for the lTRE group (95% CI: -5.10% to -1.92%). Changes in intrahepatic fat were not statistically different between the two groups. Both the eTRE and lTRE groups had similar and significant reductions in weight, visceral fat, subcutaneous fat, liver enzymes, and glucose regulatory indicators.
Conclusions
Among patients with NAFLD, both eTRE and lTRE induced significant reductions in intrahepatic fat and improvements in body composition, liver function, and metabolic health with similar magnitude. These findings suggest that eTRE and lTRE are comparable and feasible strategies for NAFLD management.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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