Financiado en parte por New Balance, New Balance Foundation
Increased low-density lipoprotein cholesterol on a low-carbohydrate diet in adults with normal but not high body weight: A meta-analysis
Soto-Mota A, Flores-Jurado Y, Norwitz NG, Feldman D, Pereira MA, Danaei G, Ludwig DS
The American journal of clinical nutrition · 26 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- New Balance
- Empresa
- New Balance Foundation
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-01-17 · Am J Clin Nutr · vol. 119 · número 3 · págs. 740–747
- Editorial
- Elsevier BV
- Citado
- 42 citas · más que el 94% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Diet and metabolism studies · Lipoproteins and Cardiovascular Health · Dietary Effects on Health
- Palabras clave
- LDL cholesterol, low-carbohydrate diet, body mass index, saturated fat intake, carbohydrate restriction, cardiovascular risk
- MeSH
- humans, cholesterol, carbohydrates, triglycerides, diet, fat-restricted, adult, overweight, diet, carbohydrate-restricted, cholesterol, ldl, cholesterol, hdl
7 autores
- Adrián Soto-Mota🇲🇽Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; Tecnológico de Monterrey
- Yuscely Flores-Jurado🇲🇽Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán; Universidad Nacional Autónoma de México
- Nicholas G. Norwitz🇺🇸Harvard University
- David Feldman
- Mark A. Pereira🇺🇸University of Minnesota
- Goodarz Danaei🇺🇸Harvard University
- David S. Ludwig🇺🇸 · autor de correspondenciaBoston Children's Hospital; Harvard University; New Balance (United States)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Low-density lipoprotein (LDL) cholesterol change with consumption of a low-carbohydrate diet (LCD) is highly variable. Identifying the source of this heterogeneity could guide clinical decision-making.
Objectives
To evaluate LDL cholesterol change in randomized controlled trials involving LCDs, with a focus on body mass index (BMI) in kg/m2.
Methods
Three electronic indexes (Pubmed, EBSCO, and Scielo) were searched for studies between 1 January, 2003 and 20 December, 2022. Two independent reviewers identified randomized controlled trials involving adults consuming <130 g/d carbohydrate and reporting BMI and LDL cholesterol change or equivalent data. Two investigators extracted relevant data, which were validated by other investigators. Data were analyzed using a random-effects model and contrasted with results of pooled individual participant data.
Results
Forty-one trials with 1379 participants and a mean intervention duration of 19.4 wk were included. In a meta-regression accounting for 51.4% of the observed variability on LCDs, mean baseline BMI had a strong inverse association with LDL cholesterol change [β = -2.5 mg/dL/BMI unit, 95% confidence interval (CI): -3.7, -1.4], whereas saturated fat amount was not significantly associated with LDL cholesterol change. For trials with mean baseline BMI <25, LDL cholesterol increased by 41 mg/dL (95% CI: 19.6, 63.3) on the LCD. By contrast, for trials with a mean of BMI 25-<35, LDL cholesterol did not change, and for trials with a mean BMI ≥35, LDL cholesterol decreased by 7 mg/dL (95% CI: -12.1, -1.3). Using individual participant data, the relationship between BMI and LDL cholesterol change was not observed on higher-carbohydrate diets.
Conclusions
A substantial increase in LDL cholesterol is likely for individuals with low but not high BMI with consumption of an LCD, findings that may help guide individualized nutritional management of cardiovascular disease risk. As carbohydrate restriction tends to improve other lipid and nonlipid risk factors, the clinical significance of isolated LDL cholesterol elevation in this context warrants investigation. This trial was registered at PROSPERO as CRD42022299278.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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