Daily Cashew and Brazil Nut Consumption Modifies Intestinal Health in Overweight Women on Energy-Restricted Intervention: A Randomized Controlled Trial (Brazilian Nuts Study)
Kelly Souza Silveira B, Mayumi Usuda Prado Rocha D, Stampini Duarte Martino H, Grancieri M, Juste Contin Gomes M, Cuquetto Mantovani H, Bressan J, Hermana Miranda Hermsdorff H
The Journal of nutrition · 16 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (428038/2018-2); Fundação de Amparo à Pesquisa do Estado de Minas Gerais (CDS-APQ-00369-17)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2024-01-20 · J Nutr · vol. 154 · número 3 · págs. 962–977
- Editorial
- Elsevier BV
- Citado
- 23 citas · más que el 92% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 93 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Gut microbiota and health · Nuts composition and effects · Nutritional Studies and Diet
- Palabras clave
- Anacardium occidentale, Bertholletia excelsa, caloric restriction, weight loss, obesity, overweight women, intestinal permeability, gut microbiota, short-chain fatty acids, propionic acid, inflammation, inflammatory cytokines, C-reactive protein, Ruminococcus, Lachnospiraceae, fat loss, lactulose/mannitol test
- MeSH
- humans, anacardium, bertholletia, nuts, obesity, inflammation, weight loss, lactulose, interleukin-8, brazil, female, overweight
8 autores
- Brenda Kelly Souza Silveira🇧🇷Universidade Federal de Viçosa
- Daniela Mayumi Usuda Prado Rocha🇧🇷Universidade Federal de Viçosa
- Hércia Stampini Duarte Martino🇧🇷Universidade Federal de Viçosa
- Mariana Grancieri🇧🇷Universidade Federal de Viçosa
- Mariana Juste Contin Gomes🇧🇷Universidade Federal de Viçosa
- Hilário Cuquetto Mantovani🇧🇷Universidade Federal de Viçosa
- Josefina Bressan🇧🇷Universidade Federal de Viçosa
- Helen Hermana Miranda Hermsdorff🇧🇷 · autor de correspondenciaUniversidade Federal de Viçosa
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Increased intestinal permeability and dysbiosis are related to obesity. Nuts can provide nutrients and bioactive compounds that modulate gut microbiota and inflammation, enhancing the beneficial effects of weight loss.
Objectives
To evaluate the effect of consuming cashew nuts (Anacardium occidentale L.) and Brazil nuts (Bertholletia excelsa H.B.K) on intestinal permeability and microbiota, fecal SCFAs and pH, inflammation, and weight loss in energy restriction condition.
Methods
In this 8-week randomized controlled trial, 40 women with overweight or obesity were assigned to energy-restricted groups (-500 kcal/d): control group (free of nuts) or Brazilian nuts group (BN: 30 g of cashew nuts and 15 g of Brazil nuts per day). Permeability was analyzed by the lactulose/mannitol test and the microbiota by sequencing the 16S gene in the V3-V4 regions. Plasma concentrations of inflammatory cytokines (TNF, IL-6, IL-10, IL-8, IL-17A) and C-reactive protein were analyzed.
Results
In total, 25 women completed the intervention. Both groups lost weight without statistical differences. Lactulose excretion increased only in the control group (P < 0.05). The BN consumption increased fecal propionic acid and potentially beneficial bacteria, such as Ruminococcus, Roseburia, strains NK4A214 and UCG-002 from the Ruminococcaceae family, but also Lachnospiraceae family, Bacteroides, and Lachnoclostridium, when compared to the control group. Changes in intestinal permeability were correlated to a greater reduction in body fat (kg), and IL-8, and increases in Ruminococcus abundance.
Conclusion
Our findings demonstrate a positive impact of BN consumption within an energy-restricted context, linked to the augmentation of potentially beneficial bacteria and pathways associated with body fat reduction. Besides, BN consumption mitigated increased intestinal permeability, although its capacity to diminish permeability or enhance weight loss proved limited. This trial was registered at the Brazilian Registry of Clinical Trials as ReBEC (ID: RBR-3ntxrm).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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