Financiado en parte por Wild Blueberry Association of North America
A biphasic response to blueberry supplementation on depressive symptoms in emerging adults: a double-blind randomized controlled trial
Velichkov M, Bezur Z, van Reekum CM, Williams CM
European journal of nutrition · 11 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- University of Reading
- Grupo de la industria
- Wild Blueberry Association of North America
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-02-01 · Eur J Nutr · vol. 63 · número 4 · págs. 1071–1088
- Editorial
- Springer Science+Business Media
- Citado
- 15 citas · más que el 90% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 79 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Treatment of Major Depression · Tryptophan and brain disorders
- Palabras clave
- depressive symptoms, emerging adults, mood, positive affect, executive function, inflammation, oxidative stress, hormesis, anhedonia, generalized anxiety disorder
- MeSH
- humans, fruit, double-blind method, depression, affect, oxidative stress, dietary supplements, adolescent, adult, female, male, young adult, executive function, biomarkers, blueberry plants
4 autores
- Martin Velichkov🇬🇧University of Reading
- Zsofia Bezur🇬🇧University of Reading
- Carien M. van Reekum🇬🇧University of Reading
- Claire Michelle Williams🇬🇧 · autor de correspondenciaUniversity of Reading
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The aim of the present study was to examine the acute and chronic effects of wild blueberry supplementation on mood, executive function, and serum biomarkers of neuroplasticity, inflammation, and oxidative stress in emerging adults with moderate-to-severe depressive symptoms.
Methods
In this double-blind trial, 60 emerging adults (Mage = 20.0 years, 32% male) with self-reported depressive symptoms were randomly assigned to receive a single blueberry drink (acute phase), followed by 6 weeks of daily blueberry supplementation (chronic phase), or a matched placebo drink. The primary outcome was Beck Depression Inventory-II (BDI-II) scores at 6-week follow-up. Further measures included momentary affect (PANAS-X) and accuracy on an executive function task. The data were analyzed using ANCOVAs adjusted for baseline values, sex, and habitual fruit and vegetable intake. Estimated marginal means were calculated to compare the treatment arms.
Results
The blueberry drink significantly improved positive affect (p = 0.026) and executive function (p = 0.025) at 2 h post-ingestion, with change scores being positively correlated in the blueberry group (r = 0.424, p = 0.017). However, after six weeks of supplementation the reduction in BDI-II scores was greater in the placebo group by 5.8 points (95% CI: 0.8-10.7, p = 0.023). Generalized anxiety and anhedonia also decreased significantly more in the placebo group. No significant differences were found for any of the biomarkers.
Conclusions
Six weeks of wild blueberry supplementation were inferior to placebo in reducing depressive symptoms. Nevertheless, the correlated improvements in positive affect and executive function after a single dose of blueberries point to a beneficial, albeit transient, psychological effect. These contrasting results suggest a biphasic, hormetic-like response that warrants further investigation.
Trial registration
NCT04647019, dated 30 November, 2020.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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