Effect of Intermittent Fasting on Lipid Profile, Anthropometric and Hepatic Markers in Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review
Castillo MF, Salgado-Canales D, Arrese M, Barrera F, Mikhailidis DP
Current vascular pharmacology · 6 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-02-04 · Curr Vasc Pharmacol · vol. 22 · número 3 · págs. 187–202
- Editorial
- Bentham Science Publishers
- Citado
- 7 citas · más que el 56% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 123 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Liver Disease Diagnosis and Treatment · Alcohol Consumption and Health Effects
- Palabras clave
- intermittent fasting, non-alcoholic fatty liver disease, time-restricted feeding, alternate-day fasting, lipid profile, anthropometric markers, hepatic steatosis, alanine aminotransferase, liver fibrosis, weight loss, fat mass reduction, cardiometabolic risk
- MeSH
- liver, humans, weight loss, lipids, treatment outcome, fasting, time factors, adult, aged, middle aged, female, male, young adult, non-alcoholic fatty liver disease, biomarkers, intermittent fasting
5 autores
- María Fernanda Castillo🇨🇱 · autor de correspondenciaUniversity of Chile
- Daniela Salgado-Canales🇨🇱Pontificia Universidad Católica de Chile
- Marco A. Arrese🇨🇱Pontificia Universidad Católica de Chile
- Francisco Barrera M.🇨🇱Pontificia Universidad Católica de Chile
- Dimitri P. Mikhailidis🇬🇧🇦🇪The Royal Free Hospital; Mohammed Bin Rashid University of Medicine and Health Sciences; University College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The first-line treatment for non-alcoholic fatty liver disease (NAFLD) is lifestyle modification; this should accompany any pharmacological intervention. Intermittent fasting (IF) has shown benefits over metabolic and cardiovascular parameters. Non-religious IF includes Time-Restricted Feeding (TRF), Alternate-Day Fasting (ADF), and 5:2 IF interventions.
Objective
To evaluate the effects of IF on anthropometric, liver damage, and lipid profile markers in subjects with NAFLD.
Methods
A bibliographic search was carried out according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines using PubMed and Scopus databases.
Results
Five studies involving 470 patients with NAFLD were included. In relation to anthropometric markers, all the articles reported body weight reduction (2.48-7.63%), but only ADF and 5:2 IF reported a body weight reduction >5%; also, all the articles reported fat mass reduction. Concerning hepatic markers, all the articles reported a reduction in hepatic steatosis and alanine aminotransferase activity, but no changes in fat-free mass and high-density lipoprotein cholesterol levels. There were variable results on fibrosis, other liver enzymes, waist circumference and body mass index, as well as the levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol.
Conclusion
Any form of IF could be potentially beneficial for NAFLD treatment and some associated cardiometabolic parameters. However, it is necessary to evaluate the effects and safety of IF in long-term studies involving a higher number of participants with different stages of NAFLD. The effect of IF on NAFLD-associated vascular risk also needs evaluation.
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