Ultra-processed food consumption and metabolic disease risk: an umbrella review of systematic reviews with meta-analyses of observational studies
Lv JL, Wei YF, Sun JN, Shi YC, Liu FH, Sun MH, Chang Q, Wu QJ, Zhao YH
Frontiers in nutrition · 22 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- China Medical University
- Gobierno
- Liaoning Revitalization Talents Program
- Universidad u hospital
- Shengjing Hospital
- Subvenciones
- Liaoning Revitalization Talents Program (XLYC1907102); Shengjing Hospital (M0268); Liaoning Revitalization Talents Program (XLYC1802095)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-01-30 · Front Nutr · vol. 11 · pág. 1306310
- Editorial
- Frontiers Media
- Citado
- 35 citas · más que el 96% de estudios similares · 4.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 75 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Diet, Metabolism, and Disease
- Palabras clave
- ultra-processed foods, metabolic disorders, obesity, type 2 diabetes, dietary guidelines, umbrella review, dietary assessment
9 autores
- Jia-Le Lv🇨🇳Sheng Jing Hospital; China Medical University
- Yifan Wei🇨🇳Sheng Jing Hospital; China Medical University
- Jianan Sun🇨🇳Sheng Jing Hospital; China Medical University
- Yuchen Shi🇨🇳Sheng Jing Hospital; China Medical University
- Fang-Hua Liu🇨🇳Sheng Jing Hospital; China Medical University
- Ming-Hui Sun🇨🇳Sheng Jing Hospital; China Medical University
- Qing Chang🇨🇳Sheng Jing Hospital; China Medical University
- Qi‐Jun Wu🇨🇳 · autor de correspondenciaSheng Jing Hospital; China Medical University
- Yuhong Zhao🇨🇳 · autor de correspondenciaSheng Jing Hospital; China Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aims
There is an ongoing debate on whether to advocate reducing ultra-processed food (UPF) in dietary guidelines to control metabolic disease (such as obesity and type 2 diabetes mellitus [T2DM]). We aimed to summarize the evidence from systematic reviews with meta-analyses between UPF consumption and metabolic diseases risk, assess the credibility, and verify the robustness of these associations.
Methods
We systematically searched PubMed, Web of Science, Embase, and Cochrane Library databases from their inception to July 15, 2023, to identify relevant systematic reviews with meta-analyses. We used the random-effects model to evaluate the summary effect size, along with 95% confidence interval and prediction interval. We also assessed heterogeneity, evidence of small-study effects and excess significance bias, and categorized the credibility of each association based on quantitative umbrella review criteria. Additionally, we conducted subgroup and sensitivity analyses to assess the robustness of associations based on continents, study design, dietary assessment methods, definition methods of UPF, population, and units of UPF consumption.
Results
Overall, 6 systematic reviews with 13 meta-analyses were included. Three (23.08%) meta-analyses were classified as highly suggestive evidence for meeting the criteria that associations were significant at p -6, had more than 1,000 cases, and presented the largest study with significance at p < 0.05. Among them, the highest UPF consumption quantile was associated with an increased risk of obesity (OR = 1.55, 95% CI: 1.36-1.77) when compared with the lowest UPF consumption quantile. The highest UPF consumption quantile was associated with an increased risk of T2DM (RR = 1.40, 95% CI: 1.23-1.59) when compared with the lowest UPF consumption quantile, and a 10% increase in UPF consumption (% g/d) was associated with an increased risk of T2DM (RR = 1.12, 95% CI: 1.10-1.13). Meanwhile, the robustness of these associations was verified by a series of subgroup and sensitivity analyses.
Conclusion
UPF consumption may be a risk factor for several metabolic diseases. However, well-designed studies are still needed to verify our findings in the future.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.