The interaction between magnesium intake, the genetic variant INSR rs1799817 and colorectal cancer risk in a Korean population: a case-control study
Nguyen LTD, Gunathilake M, Lee J, Oh JH, Chang HJ, Sohn DK, Shin A, Kim J
International journal of food sciences and nutrition · 5 citas
Cómo se estudió
- Diseño
- Estudio de casos y controles (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Research Foundation of Korea
- Gobierno
- International Cooperation & Education Program
- Universidad u hospital
- International Cooperation & Education Program of the National Cancer Center, Korea
- Universidad u hospital
- National Cancer Centre, Korea
- Subvenciones
- National Research Foundation of Korea (2021R1A2C2008439)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2024-02-22 · Int J Food Sci Nutr · vol. 75 · número 4 · págs. 396–406
- Editorial
- Taylor & Francis
- Citado
- 4 citas · más que el 68% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Digestive system and related health · Parathyroid Disorders and Treatments
- Palabras clave
- Odds ratio, Medicine, Colorectal cancer, Internal medicine, Cancer, Magnesium, Confidence interval, Case-control study, Population, Endocrinology, Oncology, Gastroenterology, Environmental health, Chemistry
- MeSH
- humans, colorectal neoplasms, genetic predisposition to disease, magnesium, receptor, insulin, antigens, cd, odds ratio, risk factors, case-control studies, polymorphism, single nucleotide, adult, aged, middle aged, female, male, republic of korea, asian people
8 autores
- Linh Thi Dieu Nguyen🇰🇷National Cancer Center
- Madhawa Neranjan Gunathilake🇰🇷National Cancer Center
- Jeonghee Lee🇰🇷National Cancer Center
- Jae Hwan Oh🇰🇷National Cancer Center; National Cancer Center Hospital
- Hee Jin Chang🇰🇷National Cancer Center; National Cancer Center Hospital
- Dae Kyung Sohn🇰🇷National Cancer Center; National Cancer Center Hospital
- Aesun Shin🇰🇷Seoul National University
- Jeongseon Kim🇰🇷 · autor de correspondenciaNational Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Magnesium may have a significant impact on the development of cancer. However, the relationship between magnesium intake and the risk of colorectal cancer (CRC) is unclear. Therefore, we evaluated the association between magnesium intake and the risk of CRC, and we investigated how the insulin receptor (INSR) rs1799817 variant impacts this relationship. Data from 1,420 CRC patients and 2,840 controls from the Korean National Cancer Centre were analysed. A higher intake of magnesium was associated with a reduced risk of CRC in the total population (odds ratio (OR) = 0.65, 95% confidence interval (CI) = 0.52-0.81). We found that G + carriers of INSR rs1799817 with higher magnesium intake had a significantly lower risk of CRC (p for interaction = 0.003). Our findings indicated that high magnesium intake could be associated with a decreased risk of CRC, and this association could be modified by the INSR rs1799817 variant.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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