The impact of intermittent fasting on gut microbiota: a systematic review of human studies
Paukkonen I, Törrönen EN, Lok J, Schwab U, El-Nezami H
Frontiers in nutrition · 36 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Itä-Suomen Yliopisto
- Gobierno
- Academy of Finland
- Subvenciones
- Academy of Finland (355462)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-02-11 · Front Nutr · vol. 11 · pág. 1342787
- Editorial
- Frontiers Media
- Citado
- 55 citas · más que el 97% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 80 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Gut microbiota and health · Genetics, Aging, and Longevity in Model Organisms
- Palabras clave
- Gut flora, Microbiome, Cochrane Library, Systematic review, Species richness, Intermittent fasting, Overweight, Human studies, Alpha diversity, Obesity, Biology, Psychological intervention, Randomized controlled trial, Medicine, Bioinformatics, MEDLINE, Ecology, Immunology, Internal medicine
5 autores
- Isa Paukkonen🇫🇮University of Eastern Finland
- Elli-Noora Törrönen🇫🇮University of Eastern Finland
- Johnson Lok🇫🇮University of Eastern Finland
- Ursula Schwab🇫🇮University of Eastern Finland; Kuopio University Hospital
- Hani S El-Nezami🇫🇮🇭🇰 · autor de correspondenciaUniversity of Eastern Finland; University of Hong Kong
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intermittent fasting (IF) has gained popularity in interventions targeting overweight, obesity and metabolic syndrome. IF may affect the gut microbiome composition and therefore have various effects on gut microbiome mediated functions in humans. Research on the effects of IF on human gut microbiome is limited. Therefore, the objective of this systematic review was to determine how different types of IF affect the human gut microbiome.
Methods
A literature search was conducted for studies investigating the association of different types of IF and gut microbiota richness, alpha and beta diversity, and composition in human subjects. Databases included Cochrane Library (RRID:SCR_013000), PubMed (RRID:SCR_004846), Scopus (RRID:SCR_022559) and Web of Science (RRID:SCR_022706). A total of 1,332 studies were retrieved, of which 940 remained after removing duplicates. Ultimately, a total of 8 studies were included in the review. The included studies were randomized controlled trials, quasi-experimental studies and pilot studies implementing an IF intervention (time-restricted eating, alternate day fasting or 5:2 diet) in healthy subjects or subjects with any disease.
Results
Most studies found an association between IF and gut microbiota richness, diversity and compositional changes. There was heterogeneity in the results, and bacteria which were found to be statistically significantly affected by IF varied widely depending on the study.
Conclusion
The findings in this systematic review suggest that IF influences gut microbiota. It seems possible that IF can improve richness and alpha diversity. Due to the substantial heterogeneity of the results, more research is required to validate these findings and clarify whether the compositional changes might be beneficial to human health.
Systematic review registration
https://www.crd.york.ac.uk/prospero/, identifier CRD42021241619.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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