Magnesium Supplementation Modulates T-cell Function in People with Type 2 Diabetes and Low Serum Magnesium Levels
Drenthen LCA, Ajie M, de Baaij JHF, Tack CJ, de Galan BE, Stienstra R
The Journal of clinical endocrinology and metabolism · 7 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Diabetes Fonds
- Organización sin fines de lucro
- Dutch Diabetes Research Foundation
- Subvenciones
- Diabetes Fonds (2017.81.014)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-02-27 · J Clin Endocrinol Metab · vol. 109 · número 12 · págs. e2240–e2245
- Editorial
- Oxford University Press
- Citado
- 9 citas · más que el 83% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 22 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- Magnesium, Type 2 diabetes, Endocrinology, Internal medicine, Function (biology), Diabetes mellitus, Cell function, Medicine, Chemistry, Cell, Biology, Biochemistry, Cell biology
- MeSH
- t-lymphocytes, cd8-positive t-lymphocytes, humans, diabetes mellitus, type 2, magnesium deficiency, magnesium, cross-over studies, double-blind method, dietary supplements, aged, middle aged, female, male
6 autores
- Linda C. A. Drenthen🇳🇱 · autor de correspondenciaRadboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Mandala Ajie🇳🇱Radboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Jeroen H. F. de Baaij🇳🇱Radboud University Nijmegen; Radboud University Medical Center
- Cees J. Tack🇳🇱Radboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences
- Bastiaan E. de Galan🇳🇱Radboud University Nijmegen; Maastricht University Medical Centre; Radboud University Medical Center; Maastricht University; Radboud Institute for Molecular Life Sciences
- Rinke Stienstra🇳🇱Radboud University Nijmegen; Radboud University Medical Center; Radboud Institute for Molecular Life Sciences; Wageningen University & Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Low magnesium levels, which are common in people with type 2 diabetes, are associated with increased levels of proinflammatory molecules. It is unknown whether magnesium supplementation decreases this low-grade inflammation in people with type 2 diabetes.
Objective
We performed multidimensional immunophenotyping to better understand the effect of magnesium supplementation on the immune system of people with type 2 diabetes and low magnesium levels.
Methods
Using a randomized, double-blind, placebo-controlled, 2-period, crossover study, we compared the effect of magnesium supplementation (15 mmol/day) with placebo on the immunophenotype, including whole blood immune cell counts, T-cell and CD14+ monocyte function after ex vivo stimulation, and the circulating inflammatory proteome.
Results
We included 12 adults with insulin-treated type 2 diabetes (7 males, mean ± SD age 67 ± 7 years, body mass index 31 ± 5 kg/m2, HbA1c 7.5 ± 0.9%) and low magnesium levels (0.73 ± 0.05 mmol/L). Magnesium treatment significantly increased serum magnesium and urinary magnesium excretion compared with placebo. Interferon-γ production from phorbol myristate acetate/ionomycin stimulated CD8+ T-cells and T-helper 1 cells, as well as interleukin (IL) 4/IL5/IL13 production from T-helper 2 cells was lower after treatment with magnesium compared with placebo. Magnesium supplementation did not affect immune cell numbers, ex vivo monocyte function, and circulating inflammatory proteins, although we found a tendency for lower high sensitivity C-reactive protein levels after magnesium supplementation compared with placebo.
Conclusion
In conclusion, magnesium supplementation modulates the function of CD4+ and CD8+ T-cells in people with type 2 diabetes and low serum magnesium levels.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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