Creatine supplementation for optimization of physical function in the patient at risk of functional disability: A systematic review and meta-analysis
Davies TW, Watson N, Pilkington JJ, McClelland TJ, Azzopardi G, Pearse RM, Prowle J, Puthucheary Z
JPEN. Journal of parenteral and enteral nutrition · 10 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Sin clasificar
- None
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Institute for Health and Care Research (ACF-2022-19-001); National Institute for Health and Care Research (ACF-2021-19-009)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2024-02-28 · JPEN J Parenter Enteral Nutr · vol. 48 · número 4 · págs. 389–405
- Editorial
- Wiley
- Citado
- 20 citas · más que el 78% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 95 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Dialysis and Renal Disease Management
- Palabras clave
- creatine supplementation, physical function, functional disability, older adults, chronic disease, sit-to-stand test, muscle strength, grip strength, lean body mass, body composition, muscle function
- MeSH
- humans, chronic disease, creatine, body composition, dietary supplements, adult, aged, middle aged, female, male, muscle strength, randomized controlled trials as topic, physical functional performance, persons with disabilities
8 autores
- Thomas Davies🇬🇧 · autor de correspondenciaQueen Mary University of London; Royal London Hospital; William Harvey Research Institute
- Naomi Watson🇬🇧Queen Mary University of London; Royal London Hospital; William Harvey Research Institute
- James Pilkington🇬🇧Manchester Metropolitan University
- Thomas J. McClelland🇬🇧Queen Mary University of London; Royal London Hospital; William Harvey Research Institute
- Giada Azzopardi🇬🇧Queen Mary University of London; Royal London Hospital; William Harvey Research Institute
- Rupert M. Pearse🇬🇧Queen Mary University of London; Royal London Hospital; William Harvey Research Institute
- John Richard Prowle🇬🇧Queen Mary University of London; Royal London Hospital; William Harvey Research Institute
- Zudin Puthucheary🇬🇧Queen Mary University of London; Royal London Hospital; William Harvey Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The efficacy of creatine replacement through supplementation for the optimization of physical function in the population at risk of functional disability is unclear.
Methods
We conducted a systematic literature search of MEDLINE, EMBASE, the Cochrane Library, and CINAHL from inception to November 2022. Studies included were randomized controlled trials (RCTs) comparing creatine supplementation with placebos in older adults and adults with chronic disease. The primary outcome was physical function measured by the sit-to-stand test after pooling data using random-effects modeling. We also performed a Bayesian meta-analysis to describe the treatment effect in probability terms. Secondary outcomes included other measures of physical function, muscle function, and body composition. The risk of bias was assessed using the Cochrane risk-of-bias tool.
Results
We identified 33 RCTs, comprising 1076 participants. From six trials reporting the primary outcome, the pooled standardized mean difference (SMD) was 0.51 (95% confidence interval [CI]: 0.01-1.00; I2 = 62%; P = 0.04); using weakly informative priors, the posterior probability that creatine supplementation improves physical function was 66.7%. Upper-body muscle strength (SMD: 0.25; 95% CI: 0.06-0.44; I2 = 0%; P = 0.01), handgrip strength (SMD 0.23; 95% CI: 0.01-0.45; I2 = 0%; P = 0.04), and lean tissue mass (MD 1.08 kg; 95% CI: 0.77-1.38; I2 = 26%; P < 0.01) improved with creatine supplementation. The quality of evidence for all outcomes was low or very low because of a high risk of bias.
Conclusion
Creatine supplementation improves sit-to-stand performance, muscle function, and lean tissue mass. It is crucial to conduct high-quality prospective RCTs to confirm these hypotheses (PROSPERO number, CRD42023354929).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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