Alternate Day Fasting Leads to Improved Post-Stroke Motor Recovery in Mice
Mersha MD, Hubbard R, Zeiler SR
Neurorehabilitation and neural repair · 1 cita
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Sin clasificar
- Jackie Lapidus
Según 1 financiador declarado.
Publicación
- Publicado
- 2024-02-29 · Neurorehabil Neural Repair · vol. 38 · número 3 · págs. 187–196
- Editorial
- SAGE Publishing
- Citado
- 2 citas · más que el 63% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Neurogenesis and neuroplasticity mechanisms · Dietary Effects on Health · Genetics, Aging, and Longevity in Model Organisms
- Palabras clave
- Stroke (engine), Forelimb, Stroke recovery, Intermittent fasting, Caloric theory, Neuroplasticity, Physical medicine and rehabilitation, Spontaneous recovery, Rehabilitation, Medicine, Psychology, Physical therapy, Neuroscience, Anesthesia, Internal medicine
- MeSH
- upper extremity, forelimb, animals, humans, mice, disease models, animal, fasting, recovery of function, stroke, stroke rehabilitation
3 autores
- Mahlet D. Mersha🇺🇸Johns Hopkins University
- Robert Hubbard🇺🇸Johns Hopkins University
- Steven R. Zeiler🇺🇸 · autor de correspondenciaJohns Hopkins University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Caloric restriction promotes neuroplasticity and recovery after neurological injury. In mice, we tested the hypothesis that caloric restriction can act post-stroke to enhance training-associated motor recovery.
Methods
Mice were trained to perform a skilled prehension task. We then induced a photothrombotic stroke in the caudal forelimb area, after which we retrained animals on the prehension task following an 8-day delay. Mice underwent either ad libitum feeding or alternate day fasting beginning 1-day after stroke and persisting for either 7 days or the entire post-stroke training period until sacrifice.
Results
Prior studies have shown that post-stroke recovery of prehension can occur if animals receive rehabilitative training during an early sensitive period but is incomplete if rehabilitative training is delayed. In contrast, we show complete recovery of prehension, despite a delay in rehabilitative training, when mice underwent alternate day fasting beginning 1-day post-stroke and persisting for either 7 days or the entire post-stroke training period until sacrifice. Recovery was independent of weight loss. Stroke volumes were similar across groups.
Conclusions
Post-stroke caloric restriction led to recovery of motor function independent of a protective effect on stroke volume. Prehension recovery improved even after ad libitum feeding was reinstituted suggesting that the observed motor recovery was not merely a motivational response. These data add to the growing evidence that post-stroke caloric restriction can enhance recovery.
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