Effect of Creatine Supplementation on Body Composition and Malnutrition-Inflammation Score in Hemodialysis Patients: An Exploratory 1-Year, Balanced, Double-Blind Design
Marini ACB, Schincaglia RM, Candow DG, Pimentel GD
Nutrients · 6 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (312252/2019–6)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-02-23 · Nutrients · vol. 16 · número 5 · pág. 615
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 9 citas · más que el 88% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dialysis and Renal Disease Management · Muscle metabolism and nutrition · Nutrition and Health in Aging
- Palabras clave
- creatine supplementation, creatine monohydrate, hemodialysis, chronic kidney disease, body composition, fat-free mass, skeletal muscle index, malnutrition-inflammation score, intracellular water, total body water, muscle atrophy
- MeSH
- muscle, skeletal, humans, malnutrition, inflammation, water, creatine, double-blind method, body composition, dietary supplements, adolescent, adult
4 autores
- Ana Clara B. Marini🇧🇷Universidade Federal de Goiás
- Raquel Machado Schincaglia🇧🇷Universidade Federal de Goiás
- Darren Glenn Candow🇨🇦University of Regina
- Gustavo D. Pimentel🇧🇷 · autor de correspondenciaUniversidade Federal de Goiás
Resumen
El texto original del estudio, en el idioma en que se publicó.
Hemodialysis has a detrimental effect on fat-free mass (FFM) and muscle strength over time. Thus, we aimed to evaluate the effect of creatine supplementation on the body composition and Malnutrition-Inflammation Score (MIS) in patients with chronic kidney disease (CKD) undergoing hemodialysis. An exploratory 1-year balanced, placebo-controlled, and double-blind design was conducted with hemodialysis patients (≥18 years). The creatine group (CG) received 5 g of creatine monohydrate and 5 g of maltodextrin per day and the placebo group (PG) received 10 g of maltodextrin per day. MIS and body composition were analyzed at three time points: pre, intermediate (after 6 months), and post (after 12 months). After 6 months, 60% of patients on creatine experienced an increase in FFM compared to a 36.8% increase for those on placebo. Moreover, 65% of patients on creatine increased their skeletal muscle mass index (SMMI) compared to only 15.8% for those on placebo. Creatine increased intracellular water (ICW) in 60% of patients. MIS did not change after the intervention. In the CG, there was an increase in body weight (p = 0.018), FFM (p = 0.010), SMMI (p = 0.022). CG also increased total body water (pre 35.4 L, post 36.1 L; p = 0.008), mainly due to ICW (pre 20.2 L, intermediate 20.7 L, post 21.0 L; p = 0.016). Long-term creatine supplementation in hemodialysis patients did not attenuate the MIS, but enhanced FFM and SMMI, which was likely triggered by an increase in ICW.
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