The effects of replacing ghee with rapeseed oil on liver steatosis and enzymes, lipid profile, insulin resistance and anthropometric measurements in patients with non-alcoholic fatty liver disease: a randomised controlled clinical trial
Maleki Sedgi F, Mohammad Hosseiniazar M, Alizadeh M
The British journal of nutrition · 8 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Urmia University
- Universidad u hospital
- Urmia University of Medical Sciences
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-03-19 · Br J Nutr · vol. 131 · número 12 · págs. 1985–1996
- Editorial
- Cambridge University Press
- Citado
- 11 citas · más que el 92% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 65 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease · Diet and metabolism studies
- Palabras clave
- Insulin resistance, Fatty liver, Medicine, Internal medicine, Steatosis, Lipid profile, Triglyceride, Gastroenterology, Body mass index, Liver disease, Insulin, Endocrinology, Cholesterol, Disease
- MeSH
- liver, humans, insulin resistance, alanine transaminase, blood glucose, lipids, anthropometry, adult, middle aged, female, male, non-alcoholic fatty liver disease, rapeseed oil
3 autores
- Fatemeh Maleki Sedgi🇮🇷Urmia University; Urmia University of Medical Sciences
- Mohammadreza Mohammad Hosseiniazar🇮🇷Urmia University; Urmia University of Medical Sciences
- Mohammad Alizadeh🇮🇷 · autor de correspondenciaUrmia University; Urmia University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Non-alcoholic fatty liver disease (NAFLD), which is a prevalent hepatic condition worldwide, is expected to develop into the leading reason for end-stage fatty liver in the forthcoming decades. Incorporating rapeseed oil into a balanced diet may be beneficial in improving NAFLD. The goal of this trial was to evaluate the impact of substituting ghee with rapeseed oil on primary outcomes such as fatty liver and liver enzymes, as well as on secondary outcomes including glycaemic variables, lipid profile and anthropometric measurements in individuals with NAFLD. Over 12 weeks, 110 patients (seventy men and forty women; BMI (mean) 28·2 (sd 1·6 kg/m2); mean age 42 (sd 9·6) years), who daily consumed ghee, were assigned to the intervention or control group through random allocation. The intervention group was advised to substitute ghee with rapeseed oil in the same amount. The control group continued the consumption of ghee and was instructed to adhere to a healthy diet. Results showed a significant reduction in the steatosis in the intervention group in comparison with the control group (P 2), waist (–5·6 cm) and waist:height ratio (–0·04) was seen in the intervention group. The consumption of rapeseed oil instead of ghee caused improvements in liver steatosis and enzymes, glycaemic variables and anthropometric measurements among individuals with NAFLD.
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