Association between dietary magnesium intake and gallstones: the mediating role of atherogenic index of plasma
Du W, Yan C, Wang Y, Song C, Li Y, Tian Z, Liu Y, Shen W
Lipids in health and disease · 23 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-03-20 · Lipids Health Dis · vol. 23 · número 1 · pág. 82
- Editorial
- BioMed Central
- Citado
- 23 citas · más que el 96% de estudios similares · 4.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Gallbladder and Bile Duct Disorders · Parathyroid Disorders and Treatments
- Palabras clave
- Gallstones, National Health and Nutrition Examination Survey, Internal medicine, Odds ratio, Medicine, Clinical chemistry, Lipidology, Clinical nutrition, Logistic regression, Gastroenterology, Dyslipidemia, Mediation, Confidence interval, Endocrinology, Physiology, Disease, Environmental health
- MeSH
- humans, gallstones, magnesium, nutrition surveys, adult, atherosclerosis
8 autores
- Wenyi Du🇨🇳Wuxi People's Hospital; Nanjing Medical University
- Chen Yan🇨🇳Tengzhou Central People's Hospital; Jining Medical University
- Yinkang Wang🇨🇳Wuxi People's Hospital; Nanjing Medical University
- Chen Song🇨🇳Wuxi People's Hospital; Nanjing Medical University
- Yunfan Li🇨🇳Jiangsu University; Affiliated Hospital of Jiangsu University
- Zhiqiang Tian🇨🇳Wuxi People's Hospital; Nanjing Medical University
- Yuan Liu🇨🇳 · autor de correspondenciaWuxi No.2 People's Hospital; Wuxi People's Hospital; Nanjing Medical University
- Wei Shen🇨🇳 · autor de correspondenciaWuxi No.2 People's Hospital; Wuxi People's Hospital; Nanjing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Dyslipidemia and abnormalities in cholesterol metabolism are commonly observed in individuals with gallstone disease. Previous research has demonstrated that dietary magnesium can influence lipid metabolism. The atherogenic index of plasma (AIP) has emerged as a novel lipid marker. This study aimed to examine the possible correlation between dietary magnesium intake and gallstones and the potential mediating role of AIP in US adults.
Methods
A total of 4,841 adults were included in this study from the National Health and Nutrition Examination Survey (NHANES) conducted from 2017 to 2020. A variety of statistical techniques such as logistic regression, subgroup analysis, smoothed curve fitting, and causal mediation analysis were utilized to analyze the information collected from the participants.
Results
In the fully adjusted model, a statistically noteworthy inverse relationship was observed between dietary magnesium intake and the presence of gallstones, as indicated by an odds ratio (OR) of 0.58 and a 95% confidence interval (CI) of (0.42, 0.81). Causal intermediary analysis revealed that the association between magnesium intake and gallstones was partially mediated by AIP, with a mediation ratio of 3.2%.
Conclusion
According to this study, dietary magnesium intake had a significant linear negative association with the prevalence of gallstones, in which AIP played a mediating role. This discovery offers novel perspectives on the prevention and management of gallstones.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.