Substitution of dietary monounsaturated fatty acids from olive oil for saturated fatty acids from lard increases low-density lipoprotein apolipoprotein B-100 fractional catabolic rate in subjects with dyslipidemia associated with insulin resistance: a randomized controlled trial
Desjardins LC, Brière F, Tremblay AJ, Rancourt-Bouchard M, Drouin-Chartier JP, Corbeil J, Lemelin V, Charest A, Schaefer EJ, Lamarche B, Couture P
The American journal of clinical nutrition · 9 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministère de la Santé et des Services sociaux
- Gobierno
- Health Canada
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- Fonds de Recherche du Québec - Santé
- Gobierno
- Fonds de recherche du Québec – Nature et technologies
- Subvenciones
- Canadian Institutes of Health Research (NUT-408430)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2024-03-20 · Am J Clin Nutr · vol. 119 · número 5 · págs. 1270–1279
- Editorial
- Elsevier BV
- Citado
- 13 citas · más que el 91% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 66 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health · Lipid metabolism and disorders
- Palabras clave
- monounsaturated fatty acids, saturated fatty acids, olive oil, lard, fat replacement, insulin resistance, dyslipidemia, apolipoprotein B-100, fractional catabolic rate, lipoprotein kinetics, LDL cholesterol, non-HDL cholesterol, sphingolipids, glycerophospholipids, lipidomics, lipoprotein metabolism
- MeSH
- humans, insulin resistance, dietary fats, fatty acids, fatty acids, monounsaturated, cross-over studies, double-blind method, adult, middle aged, female, male, dyslipidemias, apolipoprotein b-100, olive oil
11 autores
- Louis-Charles Desjardins🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF); Centre Nutrition, santé et société
- Francis Brière🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF); Centre Nutrition, santé et société
- André J Tremblay🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF); Centre Nutrition, santé et société
- Maryka Rancourt-Bouchard🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF); Centre Nutrition, santé et société
- Jean‐Philippe Drouin‐Chartier🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF); Centre Nutrition, santé et société
- Jacques Corbeil🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF); Centre Nutrition, santé et société
- Valéry Lemelin🇨🇦Centre de recherche du CHU de Québec-Université Laval; CHU de Québec-Université Laval
- Amélie Charest🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF); Centre Nutrition, santé et société
- Ernst J. Schaefer
- Benoı̂t Lamarche🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF); Centre Nutrition, santé et société
- Patrick Couture🇨🇦 · autor de correspondenciaUniversité Laval; Institut sur la nutrition et les aliments fonctionnels (INAF); Centre de recherche du CHU de Québec-Université Laval; Centre Nutrition, santé et société
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The substitution of monounsaturated acids (MUFAs) for saturated fatty acids (SFAs) is recommended for cardiovascular disease prevention but its impact on lipoprotein metabolism in subjects with dyslipidemia associated with insulin resistance (IR) remains largely unknown.
Objectives
This study aimed to evaluate the impact of substituting MUFAs for SFAs on the in vivo kinetics of apolipoprotein (apo)B-containing lipoproteins and on the plasma lipidomic profile in adults with IR-induced dyslipidemia.
Methods
Males and females with dyslipidemia associated with IR (n = 18) were recruited for this crossover double-blind randomized controlled trial. Subjects consumed, in random order, a diet rich in SFAs (SFAs: 13.4%E; MUFAs: 14.4%E) and a diet rich in MUFAs (SFAs: 7.1%E; MUFAs: 20.7%E) in fully controlled feeding conditions for periods of 4 wk each, separated by a 4-wk washout. At the end of each diet, fasting plasma samples were taken together with measurements of the in vivo kinetics of apoB-containing lipoproteins.
Results
Substituting MUFAs for SFAs had no impact on triglyceride-rich lipoprotein apoB-48 fractional catabolic rate (FCR) (Δ = -8.9%, P = 0.4) and production rate (Δ = 0.0%, P = 0.9), although it decreased very low-density lipoprotein apoB-100 pool size (PS) (Δ = -22.5%; P = 0.01). This substitution also reduced low-density lipoprotein cholesterol (LDL-C) (Δ = -7.0%; P = 0.01), non-high-density lipoprotein cholesterol (Δ = -2.5%; P = 0.04), and LDL apoB-100 PS (Δ = -6.0%; P = 0.05). These differences were partially attributed to an increase in LDL apoB-100 FCR (Δ = +1.6%; P = 0.05). The MUFA diet showed reduced sphingolipid concentrations and elevated glycerophospholipid levels compared with the SFA diet.
Conclusions
This study demonstrated that substituting dietary MUFAs for SFAs decreases LDL-C levels and LDL PS by increasing LDL apoB-100 FCR and results in an overall improved plasma lipidomic profile in individuals with IR-induced lipidemia.
Trial registration
This trial was registered as clinicaltrials.gov as NCT03872349.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.