Effects of Photobiomodulation Therapy on the Expression of Hypoxic Inducible Factor, Vascular Endothelial Growth Factor, and Its Specific Receptor: A Randomized Control Trial in Patients with Diabetic Foot Ulcer
Torkaman G, Hoseini-Sanati M, Hedayati M, Mofid M, Iranparvar Alamdari M
Photobiomodulation, photomedicine, and laser surgery · 18 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-03-27 · Photobiomodul Photomed Laser Surg · vol. 42 · número 4 · págs. 275–284
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 16 citas · más que el 94% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Wound Healing and Treatments · Diabetic Foot Ulcer Assessment and Management
- Palabras clave
- low-level laser therapy, diabetic foot ulcer, hypoxia-inducible factor-1α, vascular endothelial growth factor, VEGF receptor 2, nitric oxide, angiogenesis, wound healing, wound area
- MeSH
- humans, diabetic foot, nitric oxide, vascular endothelial growth factor receptor-2, vascular endothelial growth factor a, double-blind method, wound healing, aged, middle aged, female, male, hypoxia-inducible factor 1, alpha subunit, low-level light therapy
5 autores
- Giti Torkaman🇮🇷 · autor de correspondenciaTarbiat Modares University
- Mahsa Hoseini Sanati🇮🇷Tarbiat Modares University
- Mehdi Hedayati🇮🇷Research Institute for Endocrine Sciences; Shahid Beheshti University of Medical Sciences
- Maryam Mofid🇮🇷Hamedan University of Medical Sciences
- Manouchehr Iranparvar Alamdari🇮🇷Ardabil University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Impaired angiogenesis is a significant factor contributing to delayed healing in diabetic foot ulcers (DFUs) due to inadequate oxygenation. Objective: This study aimed to investigate the impact of photobiomodulation (PBM) using a Ga-As laser on the release of serum hypoxia-inducible factor 1-α (HIF-1α), vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2, and nitric oxide (NO) in diabetic patients with DFUs. Materials and methods: In this double-blind RCT, a total of 30 patients with grade II DFUs were enrolled. The patients were randomly divided into two groups: the PBM (n = 15) and the placebo (n = 15). In the PBM group, a Ga-As laser (904 nm, 2 J/cm2, 90 W) was given for 3 days/week for 4 weeks (11 sessions). In the placebo group, the power was turned off. Both groups received similar standard wound care. Before and after interventions, the levels of serum HIF-1α, VEGF, NO, and sVEGFR-2 were measured. In addition, the percentage decrease in the wound surface area (%DWSA) was measured. Results: Following the intervention, the results revealed that the PBM group had significantly lower levels of VEGF than the placebo group (p = 0.005). The %DWSA was significantly higher in the PBM group compared to the placebo group (p = 0.003). Moreover, VEGF showed a significant negative correlation with %DWSA (p Conclusions: The observed decrease in serum levels of VEGF and an increase in %DWSA, compared to the placebo group, suggests that PBM effectively improves angiogenesis. Furthermore, the significant correlation found between VEGF levels and %DWSA emphasizes the importance of evaluating wound surface in patients as a dependable indicator of enhanced wound angiogenesis. Clinical Trial Registration: NCT02452086.
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