The Effects of Olive Oil Consumption on Biochemical Parameters and Body Mass Index of People with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Tsamos G, Kalopitas G, Evripidou K, Vasdeki D, Koufakis T, Kanavas V, Antza C, Germanidis G, Chourdakis M
Nutrients · 6 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-03-15 · Nutrients · vol. 16 · número 6 · pág. 857
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 11 citas · más que el 77% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 67 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Liver Disease Diagnosis and Treatment · Liver Disease and Transplantation · Alcohol Consumption and Health Effects
- Palabras clave
- Nonalcoholic fatty liver disease, Medicine, Internal medicine, Meta-analysis, Aspartate transaminase, Randomized controlled trial, Alanine transaminase, Body mass index, Insulin resistance, Confidence interval, Waist, Fatty liver, Mediterranean diet, Gastroenterology, Metabolic syndrome, Obesity, Disease, Biology, Alkaline phosphatase, Biochemistry
- MeSH
- humans, body weight, body mass index, randomized controlled trials as topic, non-alcoholic fatty liver disease, olive oil
9 autores
- Georgios Tsamos🇬🇧 · autor de correspondenciaNorfolk and Norwich University Hospital
- Georgios Kalopitas🇬🇷Aristotle University of Thessaloniki; AHEPA University Hospital
- Kleo Evripidou🇬🇷Aristotle University of Thessaloniki
- Dimitra Vasdeki🇬🇷Aristotle University of Thessaloniki; AHEPA University Hospital
- Theocharis Koufakis🇬🇷Aristotle University of Thessaloniki
- Vasileios Kanavas🇬🇷University of Thessaly
- Christina Antza🇬🇷Aristotle University of Thessaloniki; Papageorgiou General Hospital
- Georgios S. Germanidis🇬🇷Aristotle University of Thessaloniki; AHEPA University Hospital
- Michail Chourdakis🇬🇷Aristotle University of Thessaloniki
Resumen
El texto original del estudio, en el idioma en que se publicó.
Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disorder, is closely associated with insulin resistance, obesity, and metabolic syndromes. A body of research has proposed that olive oil, a basic component of the Mediterranean diet with antioxidant and anti-inflammatory properties, may alleviate metabolic disturbances and retard the progression of NAFLD. We conducted a systematic review and meta-analysis to assess the effectiveness of olive oil intake in people with NAFLD. We systematically searched the major electronic databases (PubMed/MEDLINE, Scopus, Cochrane Central Register of Controlled Trials), as well as grey literature sources, to identify randomized controlled trials (RCTs) investigating the effects of olive oil consumption on biochemical and anthropometric parameters of individuals with NAFLD. The quality of the studies was evaluated using the risk-of-bias tool 2.0 (RoB 2). The mean difference (MD) and the 95% confidence interval (CI) were calculated using fixed-effects and random-effects models. Seven RCTs involving 515 subjects were included in the analysis. In the random-effects model, no statistically significant differences were identified with respect to alanine transaminase (MD = -1.83 IU/L, 95% CI: -5.85, 2.19 IU/L, p = 0.37, I2 = 69%) and aspartate transaminase (MD = -1.65 IU/L, 95% CI: -4.48, 1.17 IU/L, p = 0.25, I2 = 72%) levels or waist circumference values (MD = -0.23 cm, 95% CI: -1.23, 0.76 cm, p = 0.65, I2 = 0%). However, a significant effect on body mass index was observed (MD = -0.57 kg/m2, 95% CI: -1.08, -0.06 kg/m2, p = 0.03, I2 = 51%) for subjects who received olive oil compared to those who received an alternative diet or placebo. The findings of the present meta-analysis suggest a modestly positive impact of olive oil intake on body weight in people with NAFLD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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