Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review
Lerose V, Ponticelli M, Benedetto N, Carlucci V, Lela L, Tzvetkov NT, Milella L
Plants (Basel, Switzerland) · 25 citas
Cómo se estudió
- Diseño
- Revisión sistemática (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Sin clasificar
- >Project SPIA—Valorization of by-products from the agro-food chain
- Gobierno
- Affidamento del servizio ai sensi dell’art. 36, comma 2 lettera a) del D.L.gs
- Sin clasificar
- Project MEPLASUS: MEdicinal PLAnts in a SUstainable Supply chain. Experience of land-use practices ”-OB.FU. 2.99.99.84.00
- Gobierno
- Project RESO - REsilienza e SOstenibilità delle filiere ortofrutticole e cerealicole per valorizzare i territori" - cod. identif. ARS01_01224 -
- Gobierno
- PO FESR BASILICATA 2014–2020—Axis I—Research, Innovation Action and Technological Development—Action 1B.1.2.1—Avviso Pubblico per il sostegno alla creazione e sviluppo dei Cluster Tecnologici della Regione Basilicata e alla realizzazione di progetti di Ricerca e Sviluppo
- Gobierno
- RESO—REsilienza e SOstenibilità delle filiere ortofrutticole e cerealicole per valorizzare i territori”—cod. identif. ARS01_01224—Codice Unico Progetto (CUP)
- Sin clasificar
- Project SPIA-Valorization of by-products from the agro-food chain
- Gobierno
- Project NODES - Ecosistema dell'Innovazione "Nord Ovest Digitale e Sostenibile"
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-03-08 · Plants (Basel) · vol. 13 · número 6 · pág. 771
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 53 citas · más que el 99% de estudios similares · 9.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 149 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Medicinal Plants and Neuroprotection
- Palabras clave
- Withania somnifera, Medicine, Traditional medicine, Disease, Systematic review, Neuroprotection, Pharmacology, MEDLINE, Alternative medicine, Biology, Pathology
7 autores
- Valentina Lerose🇮🇹University of Basilicata
- Maria Ponticelli🇮🇹 · autor de correspondenciaUniversity of Basilicata
- Nadia Benedetto🇮🇹University of Basilicata
- Vittorio Carlucci🇮🇹University of Basilicata
- Ludovica Lela🇮🇹University of Basilicata
- Nikolay Tzvetkov🇧🇬Bulgarian Academy of Sciences; Institute of Molecular Biology
- Luigi Milella🇮🇹 · autor de correspondenciaUniversity of Basilicata
Resumen
El texto original del estudio, en el idioma en que se publicó.
Withania somnifera (L.) Dunal is a medicinal plant belonging to the traditional Indian medical system, showing various therapeutic effects such as anti-cancer, anti-inflammatory, anti-microbial, anti-diabetic, and hepatoprotective activity. Of great interest is W. somnifera's potential beneficial effect against neurodegenerative diseases, since the authorized medicinal treatments can only delay disease progression and provide symptomatic relief and are not without side effects. A systematic search of PubMed and Scopus databases was performed to identify preclinical and clinical studies focusing on the applications of W. somnifera in preventing neurodegenerative diseases. Only English articles and those containing the keywords (Withania somnifera AND "neurodegenerative diseases", "neuroprotective effects", "Huntington", "Parkinson", "Alzheimer", "Amyotrophic Lateral Sclerosis", "neurological disorders") in the title or abstract were considered. Reviews, editorials, letters, meta-analyses, conference papers, short surveys, and book chapters were not considered. Selected articles were grouped by pathologies and summarized, considering the mechanism of action. The quality assessment and the risk of bias were performed using the Cochrane Handbook for Systematic Reviews of Interventions checklist. This review uses a systematic approach to summarize the results from 60 investigations to highlight the potential role of W. somnifera and its specialized metabolites in treating or preventing neurodegenerative diseases.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.