Associations of Dietary Cholesterol Consumption With Incident Diabetes and Cardiovascular Disease: The Role of Genetic Variability in Cholesterol Absorption and Disease Predisposition
Shi S, Dong Y, Wang S, Du X, Feng N, Xu L, Zhong VW
Diabetes care · 4 citas
Etiquetas de revisión
Sin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Innovative Research Team of High-level Local University in Shanghai
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Key Research and Development Program of China
- Gobierno
- Shanghai Key Discipline of Public Health Grants Awards
- Subvenciones
- National Key Research and Development Program of China (2022YFC2705203 and 2023YFC2506700); National Natural Science Foundation of China (82373551)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2024-04-09 · Diabetes Care · vol. 47 · número 6 · págs. 1092–1098
- Editorial
- American Diabetes Association
- Citado
- 6 citas · más que el 88% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Genetic Associations and Epidemiology · Cholesterol and Lipid Metabolism
- Palabras clave
- Medicine, Diabetes mellitus, Genetic predisposition, Internal medicine, Hazard ratio, Cholesterol, Disease, Coronary artery disease, Type 2 diabetes, Endocrinology, Confidence interval
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, genetic predisposition to disease, cholesterol, dietary, membrane transport proteins, adult, aged, middle aged, female, male, atp binding cassette transporter, subfamily g, member 5, atp binding cassette transporter, subfamily g, member 8
7 autores
- Shuxiao Shi🇨🇳Shanghai Jiao Tong University
- Ying Dong🇨🇳Shanghai Jiao Tong University
- Sujing Wang🇨🇳Shanghai Jiao Tong University
- Xihao Du🇨🇳Shanghai Jiao Tong University
- Nannan Feng🇨🇳Shanghai Jiao Tong University
- Lan Xu🇨🇳Shanghai Jiao Tong University
- Victor W. Zhong🇨🇳 · autor de correspondenciaShanghai Jiao Tong University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Whether genetic susceptibility to disease and dietary cholesterol (DC) absorption contribute to inconsistent associations of DC consumption with diabetes and cardiovascular disease (CVD) remains unclear.
Research design and methods
DC consumption was assessed by repeated 24-h dietary recalls in the UK Biobank. A polygenetic risk score (PRS) for DC absorption was constructed using genetic variants in the Niemann-Pick C1-Like 1 and ATP Binding Cassettes G5 and G8 genes. PRSs for diabetes, coronary artery disease, and stroke were also created. The associations of DC consumption with incident diabetes (n = 96,826) and CVD (n = 94,536) in the overall sample and by PRS subgroups were evaluated using adjusted Cox models.
Results
Each additional 300 mg/day of DC consumption was associated with incident diabetes (hazard ratio [HR], 1.17 [95% CI, 1.07-1.27]) and CVD (HR, 1.09 [95% CI, 1.03-1.17]), but further adjusting for BMI nullified these associations (HR for diabetes, 0.99 [95% CI, 0.90-1.09]; HR for CVD, 1.04 [95% CI, 0.98-1.12]). Genetic susceptibility to the diseases did not modify these associations (P for interaction ≥0.06). The DC-CVD association appeared to be stronger in people with greater genetic susceptibility to cholesterol absorption assessed by the non-high-density lipoprotein cholesterol-related PRS (P for interaction = 0.04), but the stratum-level association estimates were not statistically significant.
Conclusions
DC consumption was not associated with incident diabetes and CVD, after adjusting for BMI, in the overall sample and in subgroups stratified by genetic predisposition to cholesterol absorption and the diseases. Nevertheless, whether genetic predisposition to cholesterol absorption modifies the DC-CVD association requires further investigation.
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