Association between dietary magnesium intake, inflammation, and neurodegeneration
Alateeq K, Walsh EI, Ambikairajah A, Cherbuin N
European journal of nutrition · 14 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Australian National University
- Universidad u hospital
- King Saud University
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-04-10 · Eur J Nutr · vol. 63 · número 5 · págs. 1807–1818
- Editorial
- Springer Science+Business Media
- Citado
- 21 citas · más que el 95% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 79 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Heavy Metal Exposure and Toxicity
- Palabras clave
- Inflammation, Medicine, Internal medicine, Endocrinology, White matter, Neuroprotection, C-reactive protein, Hyperintensity, National Health and Nutrition Examination Survey, Physiology, Magnetic resonance imaging, Population
- MeSH
- brain, humans, neurodegenerative diseases, inflammation, magnesium, c-reactive protein, diet, adult, aged, middle aged, female, male, biomarkers, united kingdom
4 autores
- Khawlah Alateeq🇦🇺🇸🇦 · autor de correspondenciaAustralian National University; King Saud Medical City; King Saud University
- Erin Walsh🇦🇺Australian National University
- Ananthan Ambikairajah🇦🇺Australian National University; University of Canberra
- Nicolas Cherbuin🇦🇺Australian National University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Consistent evidence shows that magnesium (Mg) intake is associated with lower blood pressure (BP), and that lower BP is associated with improved cerebral health. However, recent findings indicate that the positive effect of dietary Mg intake on cerebral health is not mediated by a decrease in BP. As Mg's anti-inflammatory action is a plausible alternative mechanism, the objective of this study was to investigate the associations between Mg intake and inflammation to determine whether it mediates any neuroprotective effect.
Methods
Participants from the UK Biobank (n = 5775, aged 40-73 years, 54.7% female) were assessed for dietary magnesium using an online food questionnaire, brain and white matter lesion (WML) volumes were segmented with FreeSurfer software, and inflammation markers including high-sensitivity C-reactive protein (hs-CRP), leukocyte, erythrocyte count, and Glycoprotein acetylation (GlycA) were measured using specific laboratory techniques such as immunoturbidimetry, automated cell counting, and nuclear magnetic resonance. Hierarchical linear regression models were performed to investigate the association between dietary Mg, and inflammatory markers and between dietary Mg, brain and WMLs volumes. Mediation analysis was performed to test a possible mediation role of inflammation on the association between dietary Mg and brain and WMLs volumes.
Results
Higher dietary Mg intake was associated with lower inflammation: hs-CRP level (- 0.0497%; 95% confidence interval [CI] - 0.0497%, - 0.0199%) leukocytes count (- 0.0015%; 95%CI - 0.00151%, - 0.0011%), and GlycA (- 0.0519%; 95%CI - 0.1298%, - 0.0129%). Moreover, higher dietary Mg intake was associated with larger grey matter volume (0.010%; 95%CI 0.004%, 0.017%), white matter volume (0.012%; 95%CI 0.003, 0.022) and right hippocampal volume (0.002%; 95%CI 0.0007, -0.0025%). Lower hs-CRP levels mediated the positive association between higher dietary Mg intake and larger grey matter volume.
Conclusions
The anti-inflammatory effects of dietary Mg intake in the general population, appears to mediate its neuroprotective effect.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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