Association of Ultraprocessed Food Consumption with Risk of Cardiovascular Disease Among Individuals with Type 2 Diabetes: Findings from the UK Biobank
Li Y, Lai Y, Geng T, Xia PF, Chen JX, Tu ZZ, Yang K, Liao YF, Liu G, Pan A
Molecular nutrition & food research · 13 citas
Etiquetas de revisión
Sin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Deutsches Krebsforschungszentrum
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Key Research and Development Program of China
- Gobierno
- Fundamental Research Funds for the Central Universities
- Gobierno
- Hubei Province Science Fund for Distinguished Young Scholars
- Gobierno
- National Basic Research Program of China
- Subvenciones
- National Key Research and Development Program of China (82073554); Fundamental Research Funds for the Central Universities (82021005); Fundamental Research Funds for the Central Universities (2021GCRC076); National Natural Science Foundation of China (82073554); National Key Research and Development Program of China (2022YFC3600600); National Natural Science Foundation of China (82 021 005); National Key Research and Development Program of China (82021005); Fundamental Research Funds for the Central Universities (81,930,124); National Natural Science Foundation of China (81930124); National Key Research and Development Program of China (82273623); National Natural Science Foundation of China (82,273,623); National Natural Science Foundation of China (2022YFC3600600); National Natural Science Foundation of China (2021CFA048); National Natural Science Foundation of China (82192902); National Key Research and Development Program of China (81930124)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2024-04-19 · Mol Nutr Food Res · vol. 68 · número 9 · pág. e2300314
- Editorial
- Wiley
- Citado
- 11 citas · más que el 94% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Nutrition, Genetics, and Disease
- Palabras clave
- Medicine, Hazard ratio, Type 2 diabetes, Internal medicine, Body mass index, Disease, Diabetes mellitus, Cystatin C, Lower risk, Confidence interval, Physiology, Endocrinology, Renal function
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, diet, risk factors, food handling, adult, aged, middle aged, female, male, united kingdom, food, processed, uk biobank
10 autores
- Yue Li🇨🇳Huazhong University of Science and Technology
- Yuwei Lai🇨🇳Huazhong University of Science and Technology
- Tingting Geng🇨🇳Fudan University; Huazhong University of Science and Technology
- Peng‐Fei Xia🇨🇳Huazhong University of Science and Technology
- Jun‐Xiang Chen🇨🇳Huazhong University of Science and Technology
- Zhou‐Zheng Tu🇨🇳Huazhong University of Science and Technology
- KUN YU YANG🇨🇳Hubei University of Medicine; Dongfeng General Hospital
- Yun‐Fei Liao🇨🇳 · autor de correspondenciaWuhan Union Hospital; Huazhong University of Science and Technology
- Gang Liu🇨🇳 · autor de correspondenciaHuazhong University of Science and Technology
- An Pan🇨🇳 · autor de correspondenciaHuazhong University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Scope
Among patients with diabetes, who have modified nutritional behavior and a higher risk of cardiovascular disease (CVD), the influence of ultraprocessed foods (UPFs) on CVD remains unknown. The study aims to evaluate the association between UPF intake and the risk of CVD among individuals with type 2 diabetes (T2D) and further examine the potential biological pathways linking the association.
Methods and results
This study includes 5405 participants with T2D who provided at least one 24-h dietary recall from the UK Biobank study. In the fully adjusted models, a 10% increase in the proportion of UPFs is associated with higher hazards of overall CVD (hazard ratio [HR]: 1.10; 95% confidence interval [CI]: 1.04, 1.15), coronary heart disease (HR: 1.10; 95% CI: 1.04, 1.16), heart failure (HR: 1.14; 95% CI: 1.05, 1.25), but not stroke (HR: 1.01; 95% CI: 0.90, 1.12). Cystatin C, high-density lipoprotein cholesterol (HDL-C), apolipoprotein A, C-reactive protein, and body mass index collectively explain 26.9% (12.8%, 48.5%) of the association between UPF intake and the risk of overall CVD.
Conclusion
Higher UPF intakes are associated with increased hazards of CVD among individuals with T2D, and the association is partly mediated through worsening biomarkers of renal function, lipid metabolism, inflammation, and body weight.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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