Acute moderate normobaric hypoxia does not modify circulating thyroid hormone concentrations induced by 1 h of head-out cold-water immersion
Keeler JM, Greenshields JT, Goss CS, Baker TB, Chapman RF, Johnson BD, Schlader ZJ
Journal of applied physiology (Bethesda, Md. : 1985) · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Office of Naval Research
- Gobierno
- DOD | USN | Office of Naval Research (ONR)
- Gobierno
- DOD | USN | Office of Naval Research
- Subvenciones
- Office of Naval Research (N00014‐20‐1‐2593); Office of Naval Research (N00014-21-1-2276)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2024-04-25 · J Appl Physiol (1985) · vol. 136 · número 6 · págs. 1400–1409
- Editorial
- American Physiological Society
- Citado
- 0 citas · más que el 6% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- High Altitude and Hypoxia · Thyroid Disorders and Treatments · Thermoregulation and physiological responses
- Palabras clave
- normobaric hypoxia, thyroid hormones, hypothalamic-pituitary-thyroid axis, thermogenesis, core body temperature, cold exposure, thyroid hormone response
- MeSH
- humans, thyrotropin, thyroid hormones, triiodothyronine, thyroxine, body temperature, cross-over studies, single-blind method, immersion, adult, female, male, cold temperature, hypoxia
7 autores
- Jason M. Keeler🇺🇸 · autor de correspondenciaIndiana University Bloomington; Indiana University
- Joel T. Greenshields🇺🇸Indiana University Bloomington; Indiana University
- Curtis S. Goss🇺🇸Indiana University Bloomington; Indiana University
- Tyler B. Baker🇺🇸Indiana University Bloomington; Indiana University
- Robert F. Chapman🇺🇸Indiana University Bloomington; Indiana University
- Blair D. Johnson🇺🇸Indiana University Bloomington; Indiana University
- Zachary J. Schlader🇺🇸 · autor de correspondenciaIndiana University Bloomington; Indiana University
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study tested the hypothesis that acute moderate normobaric hypoxia augments circulating thyroid hormone concentrations during and following 1 h of cold head-out water immersion (HOWI), compared with when cold HOWI is completed during normobaric normoxia. In a randomized crossover single-blind design, 12 healthy adults (27 ± 2 yr, 2 women) completed 1 h of cold (22.0 ± 0.1°C) HOWI breathing either normobaric normoxia ([Formula: see text] = 0.21) or normobaric hypoxia ([Formula: see text] = 0.14). Free and total thyroxine (T3) and triiodothyronine (T4), and thyroid-stimulating hormone (TSH) concentrations were measured in venous blood samples obtained before (baseline), during (15-, 30-, and 60 min), and 15 min following HOWI (post-), and were corrected for changes in plasma volume. Arterial oxyhemoglobin saturation and core (rectal) temperature were measured continuously. Arterial oxyhemoglobin saturation was lower during hypoxia (90 ± 3%) compared with normoxia (98 ± 1%, P P P = 0.552). Circulating TSH, total T3, free T4, total T3, and free T4 concentrations demonstrated significant main effects of time (all P ≤ 0.024), but these changes did not differ between normoxic and hypoxic conditions (condition × time: all P ≥ 0.163). These data indicate that acute moderate normobaric hypoxia does not modify the circulating thyroid hormone response during 1 h of cold HOWI.NEW & NOTEWORTHY Acute head-out cold (22°C) water immersion (HOWI) decreased core temperature and increased thermogenesis. This thermogenic response was paralleled by the activation of the hypothalamic-pituitary-thyroid axis, as evidenced by changes in thyroid hormones. However, cold HOWI in combination with moderate normobaric hypoxia did not modify the thermogenic nor the circulating thyroid hormone response. This finding suggests that hypoxia-induced alterations in thyroid hormone concentrations are unlikely to acutely contribute to adaptations resulting from repeated cold-water exposures.
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