Association between processed and unprocessed red meat consumption and risk of nonalcoholic fatty liver disease: A systematic review and dose-response meta-analysis
Zhou Q, Hu H, Hu L, Liu S, Chen J, Tong S
Journal of global health · 16 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-04-26 · J Glob Health · vol. 14 · pág. 04060
- Editorial
- Edinburgh University Global Health Society
- Citado
- 17 citas · más que el 87% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 69 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Meat and Animal Product Quality · Liver Disease Diagnosis and Treatment
- Palabras clave
- Nonalcoholic fatty liver disease, Meta-analysis, Processed meat, Medicine, Red meat, Environmental health, Food science, MEDLINE, Association (psychology), Internal medicine, Fatty liver, Disease, Physiology, Biology, Psychology, Biochemistry
- MeSH
- humans, risk factors, food handling, meat products, non-alcoholic fatty liver disease, red meat
6 autores
- Qin Zhou🇨🇳Dalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Huaidong Hu🇨🇳First People's Hospital of Chongqing
- Lina Hu🇨🇳Dalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Shuaibin Liu🇨🇳Dalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
- Jin Chen🇨🇳West China Medical Center of Sichuan University
- Shiwen Tong🇨🇳Dalian Medical University; Second Affiliated Hospital of Chongqing Medical University; Chongqing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The nature of the relationship between red meat consumption and nonalcoholic fatty liver disease (NAFLD) remains unclear. Through this meta-analysis, we aimed to determine the association and dose-response relationship between red meat consumption (both processed and unprocessed) and the risk of NAFLD.
Methods
We systematically searched CENTRAL, PubMed, Embase, Web of Science and Scopus from inception to February 2022 for observational studies in which the exposure of interest was red meat consumption; the outcome of interest was the risk of NAFLD; and where odds ratios (ORs) or risk ratios were provided or could be calculated. We used random-effects meta-analyses to pool the effect sizes and performed analyses to estimate the linearity of the dose-response relationships between red meat intake and NAFLD risk.
Results
We included 10 studies in this review. The meta-analysis showed a significant association between the intake of red meat (OR = 1.27; 95% confidence interval (CI) = 1.07-1.50, P = 0.000, I2 = 81%), processed red meat (OR = 1.20; 95% CI = 1.04-1.3, P = 0.162, I2 = 34.9%) or unprocessed red meat (OR = 1.28; 95% CI = 1.05-1.55, P = 0.001, I2 = 76.2%) and the risk of NAFLD. We also found a significant linear dose-response association between processed red meat intake and NAFLD, with each 25-g increment of processed red meat intake per day was associated with an 11.1% higher risk of NAFLD (OR = 1.11; 95% CI = 1.01-1.22, P = 0.029), and a nonlinear association between unprocessed meat intake and NAFLD (P = 0.003 for nonlinearity).
Conclusions
Our findings indicate a potential positive association between red meat consumption (both processed and unprocessed) and NAFLD risk, especially in relation to increased intake of processed red meat compared to unprocessed red meat. However, caution is advised in interpreting these results; further research could establish a clearer understanding of the relationship between red meat consumption and NAFLD risk.
Registration
PROSPERO: CRD42022332839.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.