Financiado en parte por Amgen, Sanofi, Alexion Pharmaceuticals, DSM Nutritional Products, UCB Pharma, Abiogen Pharma
Consensus Statement on Vitamin D Status Assessment and Supplementation: Whys, Whens, and Hows
Giustina A, Bilezikian JP, Adler RA, Banfi G, Bikle DD, Binkley NC, Bollerslev J, Bouillon R, Brandi ML, Casanueva FF, di Filippo L, Donini LM, Ebeling PR, Fuleihan GE, Fassio A, Frara S, Jones G, Marcocci C, Martineau AR, Minisola S, Napoli N, Procopio M, Rizzoli R, Schafer AL, Sempos CT, Ulivieri FM, Virtanen JK
Endocrine reviews · 275 citas
Etiquetas de revisión
Vínculos de autores con la industriaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ficha de expertos o del gobierno (clasificado por nuestro filtro de IA)
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Amgen
- Empresa
- Sanofi
- Empresa
- Alexion Pharmaceuticals
- Universidad u hospital
- Oregon State University
- Organización sin fines de lucro
- Barts Charity
- Gobierno
- National Institute for Health and Care Research
- Empresa
- DSM Nutritional Products
- Gobierno
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Empresa
- UCB Pharma
- Gobierno
- NIAMS NIH HHS
- Empresa
- Abiogen Pharma
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR075055)
Según 11 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-04-27 · Endocr Rev · vol. 45 · número 5 · págs. 625–654
- Editorial
- Oxford University Press
- Citado
- 349 citas · más que el 100% de estudios similares · 98.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 282 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Bone health and osteoporosis research
- Palabras clave
- Vitamin D and neurology, Medicine, Clinical trial, Cholecalciferol, Osteomalacia, Vitamin, Diabetes mellitus, vitamin D deficiency, Intensive care medicine, Internal medicine, Physiology, Endocrinology
- MeSH
- humans, vitamin d deficiency, vitamin d, dietary supplements, review literature as topic
27 autores
- Andrea Giustina🇮🇹Vita-Salute San Raffaele University
- John Paul Bilezikian · autor de correspondencia
- Robert A. Adler🇺🇸Virginia Commonwealth University
- Giuseppe Banfi🇮🇹Vita-Salute San Raffaele University; Istituto Clinico Sant'Ambrogio
- Daniel D. Bikle🇺🇸San Francisco VA Medical Center
- Neil Binkley🇺🇸University of Wisconsin–Madison
- Jens Bollerslev🇳🇴University of Oslo
- Roger Bouillon🇧🇪KU Leuven
- Maria Luisa Brandi
- Felipe F. Casanueva🇪🇸Centro de Investigación Biomédica en Red; Instituto de Investigación Sanitaria de Santiago
- Luigi di Filippo🇮🇹Vita-Salute San Raffaele University
- Lorenzo M. Donini🇮🇹Sapienza University of Rome
- Peter Robert Ebeling🇦🇺Monash University
- Ghada El‐Hajj Fuleihan🇱🇧American University of Beirut
- Angelo Fassio🇮🇹University of Verona
- Stefano Frara🇮🇹Vita-Salute San Raffaele University
- Glenville Jones🇨🇦Queen's University
- Claudio Marcocci🇮🇹University of Pisa
- Adrian R. Martineau🇬🇧Queen Mary University of London
- Salvatore Minisola🇮🇹Sapienza University of Rome
- Nicola Napoli🇮🇹Università Campus Bio-Medico
- Massimo Procopio🇮🇹Fondazione Ricerca Molinette; University of Turin
- René Rizzoli🇨🇭University Hospital of Geneva
- Anne L. Schafer🇺🇸San Francisco VA Medical Center
- Christopher T. Sempos🇺🇸Grace (United States)
- Fabio Massimo Ulivieri🇮🇹Vita-Salute San Raffaele University
- Jyrki K. Virtanen🇫🇮University of Eastern Finland
Resumen
El texto original del estudio, en el idioma en que se publicó.
The 6th International Conference, "Controversies in Vitamin D," was convened to discuss controversial topics, such as vitamin D metabolism, assessment, actions, and supplementation. Novel insights into vitamin D mechanisms of action suggest links with conditions that do not depend only on reduced solar exposure or diet intake and that can be detected with distinctive noncanonical vitamin D metabolites. Optimal 25-hydroxyvitamin D (25(OH)D) levels remain debated. Varying recommendations from different societies arise from evaluating different clinical or public health approaches. The lack of assay standardization also poses challenges in interpreting data from available studies, hindering rational data pooling and meta-analyses. Beyond the well-known skeletal features, interest in vitamin D's extraskeletal effects has led to clinical trials on cancer, cardiovascular risk, respiratory effects, autoimmune diseases, diabetes, and mortality. The initial negative results are likely due to enrollment of vitamin D-replete individuals. Subsequent post hoc analyses have suggested, nevertheless, potential benefits in reducing cancer incidence, autoimmune diseases, cardiovascular events, and diabetes. Oral administration of vitamin D is the preferred route. Parenteral administration is reserved for specific clinical situations. Cholecalciferol is favored due to safety and minimal monitoring requirements. Calcifediol may be used in certain conditions, while calcitriol should be limited to specific disorders in which the active metabolite is not readily produced in vivo. Further studies are needed to investigate vitamin D effects in relation to the different recommended 25(OH)D levels and the efficacy of the different supplementary formulations in achieving biochemical and clinical outcomes within the multifaced skeletal and extraskeletal potential effects of vitamin D.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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