Does Yogurt Enriched with Platelet-Activating Factor Inhibitors from Olive Oil By-Products Affect Gut Microbiota and Faecal Metabolites in Healthy Overweight Subjects? (A randomized, parallel, three arm trial.)
Antonopoulou S, Mitsou EK, Kyriacou A, Fragopoulou E, Detopoulou M
Frontiers in bioscience (Landmark edition) · 4 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Regional Development Fund of the EU and the Greek Ministry of Education and Religious Affairs, Sport and Culture/GGET - ЕΥDЕ-ЕΤАΚ
- Gobierno
- European Regional Development Fund of the EU and the Greek Ministry of Education and Religious Affairs, Sport and Culture/GGET – ЕΥDЕ-ЕΤАΚ
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-04-23 · Front Biosci (Landmark Ed) · vol. 29 · número 4 · pág. 159
- Editorial
- IMR Press
- Citado
- 4 citas · más que el 54% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 73 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Gut microbiota and health · Probiotics and Fermented Foods · Microbial Metabolites in Food Biotechnology
- Palabras clave
- platelet-activating factor receptor antagonist, olive oil by-products, gut microbiota, fecal metabolites, overweight, Bifidobacterium, Clostridium perfringens, Firmicutes/Bacteroidetes ratio, platelet aggregation, volatile fatty acids, hexanoic acid, butyrate, cardiovascular risk
- MeSH
- feces, humans, platelet activating factor, platelet membrane glycoproteins, receptors, g-protein-coupled, double-blind method, yogurt, adult, middle aged, female, male, overweight, olive oil, gastrointestinal microbiome
5 autores
- Smaragdi Antonopoulou🇬🇷 · autor de correspondenciaHarokopio University of Athens
- Evdokia K. Mitsou🇬🇷Harokopio University of Athens
- Adamantini Kyriacou🇬🇷Harokopio University of Athens
- Elizabeth Fragopoulou🇬🇷Harokopio University of Athens
- Maria Detopoulou🇬🇷Harokopio University of Athens
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The effect of the daily consumption of a low-fat yogurt (150 g) enriched with Platelet-Activating Factor receptor (PAF-R) antagonists, or the plain one, on gut microbiota and faecal metabolites was investigated in healthy overweight subjects.
Methods
A randomized, three-arm, double-blind, placebo-controlled, parallel-group study was performed that lasted 8 weeks. Blood and stools were collected and analyzed before and after the intervention.
Results
Our findings revealed that the intake of the enriched yogurt resulted in a significant increase in the levels of Bifidobacterium spp., Clostridium perfringens group and Firmicutes-to-Bacteroidetes (F/B) ratio. On the other hand, a significant increase in the levels of Lactobacillus and C. perfringens group was detected after the intake of the plain yogurt. The increase in the levels of C. perfringens group was inversely associated with the plasma catabolic enzyme of PAF, namely LpPLA2 (lipoprotein-associated phospholipase A2), a cardiovascular risk marker that has been linked with inflammation and atherosclerosis. Moreover, in the enriched with PAF-R antagonists yogurt group, the increased levels of C. perfringens group were also associated with lower PAF action assessed as ex vivo human platelet-rich plasma (PRP) aggregation. Additionally, a higher % increase in molar ratio of Branched Short Chain Fatty Acids (BSCFAs) was detected for both yogurt groups after the 8 week-intervention compared to control. The consumption of the enriched yogurt also resulted in a significant drop in faecal caproic levels and a trend for lower ratio of butyrate to total volatile fatty acids (VFAs) compared to baseline levels.
Conclusion
Yogurt consumption seems to favorably affect gut microbiota while its enrichment with PAF-R antagonists from olive oil by-products, may provide further benefits in healthy overweight subjects.
Clinical trial registration
ClinicalTrials.gov (NCT02259205).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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