Ultra-processed foods and human health: An umbrella review and updated meta-analyses of observational evidence
Dai S, Wellens J, Yang N, Li D, Wang J, Wang L, Yuan S, He Y, Song P, Munger R, Kent MP, MacFarlane AJ, Mullie P, Duthie S, Little J, Theodoratou E, Li X
Clinical nutrition (Edinburgh, Scotland) · 75 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Cancer Research UK
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Fonds Wetenschappelijk Onderzoek
- Gobierno
- Vlaamse regering
- Gobierno
- Natural Science Foundation of Sichuan Province
- Gobierno
- Science Fund for Distinguished Young Scholars of Zhejiang Province
- Subvenciones
- Cancer Research UK (C31250/A22804); Natural Science Foundation of Sichuan Province (2022NSFSC1314); Science Fund for Distinguished Young Scholars of Zhejiang Province (C31250/A22804); Fonds Wetenschappelijk Onderzoek (1S06023N); Science Fund for Distinguished Young Scholars of Zhejiang Province (LR22H260001); National Natural Science Foundation of China (82204019)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2024-04-17 · Clin Nutr · vol. 43 · número 6 · págs. 1386–1394
- Editorial
- Elsevier BV
- Citado
- 142 citas · más que el 100% de estudios similares · 53.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 113 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease · Dye analysis and toxicity
- Palabras clave
- Medicine, Observational study, Environmental health, Intensive care medicine, Pathology
- MeSH
- humans, diet, food handling, female, meta-analysis as topic, fast foods, observational studies as topic, food, processed
17 autores
- Shuhui Dai🇨🇳Second Affiliated Hospital of Zhejiang University
- Judith Wellens🇬🇧🇧🇪John Radcliffe Hospital; KU Leuven
- Nan Yang🇨🇳Second Affiliated Hospital of Zhejiang University
- Doudou Li🇨🇳Zhengzhou University
- Jingjing Wang🇨🇳Second Affiliated Hospital of Zhejiang University
- Lijuan Wang🇨🇳🇬🇧Second Affiliated Hospital of Zhejiang University; University of Edinburgh
- Shuai Yuan🇸🇪🇨🇳Karolinska Institutet; Second Affiliated Hospital of Zhejiang University
- Yazhou He🇨🇳Sichuan University
- Peige Song🇨🇳Women's Hospital, School of Medicine, Zhejiang University
- Ron Munger🇺🇸Utah State University
- Monique Potvin Kent🇨🇦University of Ottawa
- Amanda J MacFarlane🇨🇦Health Canada
- Patrick Mullie🇫🇷🇧🇪International Prevention Research Institute; Belgian Road Research Centre
- Susan J. Duthie🇬🇧Robert Gordon University
- Julian Little🇨🇦University of Ottawa
- Evropi Τheodoratou🇬🇧Edinburgh Cancer Research; University of Edinburgh
- Xue Li🇨🇳 · autor de correspondenciaSecond Affiliated Hospital of Zhejiang University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Ultra-processed food (UPF) intake has increased sharply over the last few decades and has been consistently asserted to be implicated in the development of non-communicable diseases. We aimed to evaluate and update the existing observational evidence for associations between ultra-processed food (UPF) consumption and human health.
Methods
We searched Medline and Embase from inception to March 2023 to identify and update meta-analyses of observational studies examining the associations between UPF consumption, as defined by the NOVA classification, and a wide spectrum of health outcomes. For each health outcome, we estimated the summary effect size, 95% confidence interval (CI), between-study heterogeneity, evidence of small-study effects, and evidence of excess-significance bias. These metrics were used to evaluate evidence credibility of the identified associations.
Results
This umbrella review identified 39 meta-analyses on the associations between UPF consumption and health outcomes. We updated all meta-analyses by including 122 individual articles on 49 unique health outcomes. The majority of the included studies divided UPF consumption into quartiles, with the lowest quartile being the reference group. We identified 25 health outcomes associated with UPF consumption. For observational studies, 2 health outcomes, including renal function decline (OR: 1.25; 95% CI: 1.18, 1.33) and wheezing in children and adolescents (OR: 1.42; 95% CI: 1.34, 1.49), showed convincing evidence (Class I); and five outcomes were reported with highly suggestive evidence (Class II), including diabetes mellitus, overweight, obesity, depression, and common mental disorders.
Conclusions
High UPF consumption is associated with an increased risk of a variety of chronic diseases and mental health disorders. At present, not a single study reported an association between UPF intake and a beneficial health outcome. These findings suggest that dietary patterns with low consumption of UPFs may render broad public health benefits.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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