Intermittent Fasting After ST-Segment-Elevation Myocardial Infarction Improves Left Ventricular Function: The Randomized Controlled INTERFAST-MI Trial
Dutzmann J, Kefalianakis Z, Kahles F, Daniel JM, Gufler H, Wohlgemuth WA, Knöpp K, Sedding DG
Circulation. Heart failure · 15 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-05-01 · Circ Heart Fail · vol. 17 · número 5 · pág. e010936
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 17 citas · más que el 94% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 26 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Acute Myocardial Infarction Research · Cardiovascular Function and Risk Factors
- Palabras clave
- intermittent fasting, ST-elevation myocardial infarction, left ventricular ejection fraction, left ventricular function, diastolic blood pressure, weight loss, dietary adherence
- MeSH
- humans, stroke volume, treatment outcome, fasting, prospective studies, ventricular function, left, time factors, aged, middle aged, female, male, st elevation myocardial infarction, intermittent fasting
8 autores
- Jochen Dutzmann🇩🇪University Hospital in Halle
- Zoe Kefalianakis🇩🇪University Hospital in Halle
- Florian Kahles🇩🇪Universitätsklinikum Aachen
- Jan‐Marcus Daniel🇩🇪University Hospital in Halle
- Hubert Gufler🇩🇪University Hospital in Halle
- Walter Alexander Wohlgemuth🇩🇪University Hospital in Halle
- Kai Knöpp🇩🇪University Hospital in Halle
- Daniel Sedding🇩🇪University Hospital in Halle
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intermittent fasting has shown positive effects on numerous cardiovascular risk factors. The INTERFAST-MI trial (Intermittent Fasting in Myocardial Infarction) has been designed to study the effects of intermittent fasting on cardiac function after STEM (ST-segment-elevation myocardial infarction) and the feasibility of future multicenter trials.
Methods
The INTERFAST-MI study was a prospective, randomized, controlled, nonblinded, single-center investigator-initiated trial. From October 1, 2020, to July 15, 2022, 48 patients were randomized to the study groups intermittent fasting or regular diet and followed for 6 months with follow-up visits at 4 weeks and 3 months.
Results
In all, 22 of 24 patients in the intermittent fasting group with a mean age of 58.54±12.29 years and 20 of 24 patients in the regular diet group with a mean age of 59.60±13.11 years were included in the intention-to-treat population. The primary efficacy end point (improvement in left ventricular ejection fraction after 4 weeks) was significantly greater in the intermittent fasting group compared with the control group (mean±SD, 6.636±7.122%. versus 1.450±4.828%; P=0.038). This effect was still significant and even more pronounced after 3 and 6 months. The patients in the intermittent fasting group showed a greater reduction in diastolic blood pressure and body weight compared with the control group. The mean adherence of patients in the intermittent fasting group was a median of 83.7% (interquartile range, 69.0%-98.4%) of all days. None of the patients from either group reported dizziness, syncope, or collapse.
Conclusions
Our results suggest that intermittent fasting after myocardial infarction may be safe and could improve left ventricular function after STEMI.
Registration
URL: https://www.drks.de; Unique identifier: DRKS00021784.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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