Relationships between nitric oxide biomarkers and physiological outcomes following dietary nitrate supplementation
Wei C, Vanhatalo A, Black MI, Blackwell JR, Rajaram R, Kadach S, Jones AM
Nitric oxide : biology and chemistry · 16 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Exeter
- Gobierno
- China Scholarship Council
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-05-01 · Nitric Oxide · vol. 148 · págs. 23–33
- Editorial
- Elsevier BV
- Citado
- 15 citas · más que el 97% de estudios similares · 7.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · Heart Rate Variability and Autonomic Control
- Palabras clave
- Nitric oxide, Crossover study, Nitrite, Bioavailability, Blood pressure, Chemistry, Ingestion, Internal medicine, Placebo, Endocrinology, Isometric exercise, Biomarker, Skeletal muscle, Nitrate, Animal science, Medicine, Biochemistry, Pharmacology, Biology
- MeSH
- muscle, skeletal, humans, beta vulgaris, nitrates, nitrites, nitric oxide, cross-over studies, double-blind method, blood pressure, dietary supplements, adult, female, male, young adult, biomarkers
7 autores
- Chenguang Wei🇬🇧University of Exeter
- Anni Vanhatalo🇬🇧University of Exeter
- Matthew I. Black🇬🇧University of Exeter
- Jamie R. Blackwell🇬🇧University of Exeter
- Raghini Rajaram🇬🇧University of Exeter
- Stefan Kadach🇬🇧University of Exeter
- ANDREW MARK JONES🇬🇧 · autor de correspondenciaUniversity of Exeter
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary nitrate (NO3-) supplementation can increase nitric oxide (NO) bioavailability, reduce blood pressure (BP) and improve muscle contractile function in humans. Plasma nitrite concentration (plasma [NO2-]) is the most oft-used biomarker of NO bioavailability. However, it is unclear which of several NO biomarkers (NO3-, NO2-, S-nitrosothiols (RSNOs)) in plasma, whole blood (WB), red blood cells (RBC) and skeletal muscle correlate with the physiological effects of acute and chronic dietary NO3- supplementation. Using a randomized, double-blind, crossover design, 12 participants (9 males) consumed NO3--rich beetroot juice (BR) (∼12.8 mmol NO3-) and NO3--depleted placebo beetroot juice (PL) acutely and then chronically (for two weeks). Biological samples were collected, resting BP was assessed, and 10 maximal voluntary isometric contractions of the knee extensors were performed at 2.5-3.5 h following supplement ingestion on day 1 and day 14. Diastolic BP was significantly lower in BR (-2 ± 3 mmHg, P = 0.03) compared to PL following acute supplementation, while the absolute rate of torque development (RTD) was significantly greater in BR at 0-30 ms (39 ± 57 N m s-1, P = 0.03) and 0-50 ms (79 ± 99 N m s-1, P = 0.02) compared to PL following two weeks supplementation. Greater WB [RSNOs] rather than plasma [NO2-] was correlated with lower diastolic BP (r = -0.68, P = 0.02) in BR compared to PL following acute supplementation, while greater skeletal muscle [NO3-] was correlated with greater RTD at 0-30 ms (r = 0.64, P=0.03) in BR compared to PL following chronic supplementation. We conclude that [RSNOs] in blood, and [NO3-] in skeletal muscle, are relevant biomarkers of NO bioavailability which are related to the reduction of BP and the enhanced muscle contractile function following dietary NO3- ingestion in humans.
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