Association of ultra-processed food consumption with all cause and cause specific mortality: population based cohort study
Fang Z, Rossato SL, Hang D, Khandpur N, Wang K, Lo CH, Willett WC, Giovannucci EL, Song M
BMJ (Clinical research ed.) · 76 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- Centers for Disease Control and Prevention
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (U01 CA167552); National Cancer Institute (CA-167552); National Cancer Institute (UM1 CA186107); National Cancer Institute (CA-87969); National Cancer Institute (CA-186107); National Cancer Institute (K99 CA283146); National Cancer Institute (U01CA261961); National Cancer Institute ([P01 CA87969); National Institutes of Health (U01-CA167552); National Institutes of Health (P01 CA 87969); National Institutes of Health (U01 CA261961); National Institutes of Health (UM1‐CA‐186107); National Institutes of Health (CA-167552); National Institutes of Health (CA186107); National Institutes of Health (CA 87969); National Institutes of Health (R01CA263776)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2024-05-08 · BMJ · vol. 385 · pág. e078476
- Citado
- 94 citas · más que el 100% de estudios similares · 35.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Sodium Intake and Health
- Palabras clave
- Cohort, Consumption (sociology), Population, Cohort study, Environmental health, Medicine, Computer science, Internal medicine
- MeSH
- humans, neoplasms, cardiovascular diseases, mortality, cause of death, proportional hazards models, risk factors, cohort studies, food handling, adult, aged, middle aged, united states, female, male, food, processed
9 autores
- Zhe Fang🇺🇸Harvard University
- Sinara Laurini Rossato🇺🇸🇧🇷Harvard University; Universidade Federal de Uberlândia
- Dong Hang🇺🇸🇨🇳Harvard University; Nanjing Medical University
- Neha Khandpur🇺🇸🇧🇷🇳🇱Harvard University; Universidade de São Paulo; Wageningen University & Research
- Kai Wang🇺🇸Harvard University
- Chun‐Han Lo🇺🇸University of Nevada, Las Vegas
- Walter Churchill Willett🇺🇸Brigham and Women's Hospital; Harvard University
- Edward L. Giovannucci🇺🇸Harvard University
- Mingyang Song🇺🇸 · autor de correspondenciaHarvard University; Massachusetts General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To examine the association of ultra-processed food consumption with all cause mortality and cause specific mortality.
Design
Population based cohort study.
Setting
Female registered nurses from 11 US states in the Nurses' Health Study (1984-2018) and male health professionals from all 50 US states in the Health Professionals Follow-up Study (1986-2018).
Participants
74 563 women and 39 501 men with no history of cancer, cardiovascular diseases, or diabetes at baseline.
Main outcome measures
Multivariable Cox proportional hazard models were used to estimate hazard ratios and 95% confidence intervals for the association of ultra-processed food intake measured by semiquantitative food frequency questionnaire every four years with all cause mortality and cause specific mortality due to cancer, cardiovascular, and other causes (including respiratory and neurodegenerative causes).
Results
30 188 deaths of women and 18 005 deaths of men were documented during a median of 34 and 31 years of follow-up, respectively. Compared with those in the lowest quarter of ultra-processed food consumption, participants in the highest quarter had a 4% higher all cause mortality (hazard ratio 1.04, 95% confidence interval 1.01 to 1.07) and 9% higher mortality from causes other than cancer or cardiovascular diseases (1.09, 1.05 to 1.13). The all cause mortality rate among participants in the lowest and highest quarter was 1472 and 1536 per 100 000 person years, respectively. No associations were found for cancer or cardiovascular mortality. Meat/poultry/seafood based ready-to-eat products (for example, processed meat) consistently showed strong associations with mortality outcomes (hazard ratios ranged from 1.06 to 1.43). Sugar sweetened and artificially sweetened beverages (1.09, 1.07 to 1.12), dairy based desserts (1.07, 1.04 to 1.10), and ultra-processed breakfast food (1.04, 1.02 to 1.07) were also associated with higher all cause mortality. No consistent associations between ultra-processed foods and mortality were observed within each quarter of dietary quality assessed by the Alternative Healthy Eating Index-2010 score, whereas better dietary quality showed an inverse association with mortality within each quarter of ultra-processed foods.
Conclusions
This study found that a higher intake of ultra-processed foods was associated with slightly higher all cause mortality, driven by causes other than cancer and cardiovascular diseases. The associations varied across subgroups of ultra-processed foods, with meat/poultry/seafood based ready-to-eat products showing particularly strong associations with mortality.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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