Low-level red-light therapy for myopia control in children: A systematic review and meta-analysis
Amaral DC, Batista S, Dos Santos-Neto E, Manso JEF, Rodrigues MPM, Monteiro MLR, Alves MR, Louzada RN
Clinics (Sao Paulo, Brazil) · 19 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-01-01 · Clinics (Sao Paulo) · vol. 79 · pág. 100375
- Editorial
- Elsevier BV
- Citado
- 20 citas · más que el 89% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 23 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Laser Applications in Dentistry and Medicine · Corneal surgery and disorders
- Palabras clave
- Meta-analysis, Medicine, Light therapy, MEDLINE, Psychology, Internal medicine, Political science
- MeSH
- humans, myopia, treatment outcome, adolescent, child, child, preschool, female, male, randomized controlled trials as topic, low-level light therapy
8 autores
- Dillan Cunha Amaral🇧🇷Universidade Federal do Rio de Janeiro
- Sávio Batista🇧🇷Universidade Federal do Rio de Janeiro
- Edson dos Santos-Neto🇧🇷Universidade de São Paulo
- José Eduardo Ferreira Manso🇧🇷Universidade Federal do Rio de Janeiro
- Márcio Penha Morterá Rodrigues🇧🇷Universidade Federal do Rio de Janeiro
- Mário Luiz Ribeiro Monteiro🇧🇷Universidade de São Paulo
- Mílton Ruiz Alves🇧🇷Universidade de São Paulo
- Ricardo Noguera Louzada🇧🇷 · autor de correspondenciaUniversidade Federal do Rio de Janeiro; Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Low-Level Red-Light (LLRL) Therapy is a safe and natural way to promote healing and reduce inflammation in the body. When it comes to treating myopia in children, LLRL therapy is recent, and its efficacy and safety still are not clear.
Methods
A systematic review and meta-analysis of the literature for LLRL was conducted in accordance with the PRISMA guidelines on November 5, 2022. Databases, including PUBMED, Cochrane Library, Web of Science, and Embase were queried. A meta-analysis of random effects was conducted. Inclusion criteria included Randomized Controlled Trials (RCTs) or observational studies where LLRL therapy was used in children (3‒15 years old) with myopia. Exclusion criteria were studies with other ocular abnormalities. Efficacy was evaluated through the mean change in Axial Length (AL) and cycloplegic Spherical Equivalent Error (SER), while safety was evaluated by monitoring adverse effects.
Results
A total of 5 final studies were included (4 RCTs, and 1 observational), in which 685 total patients were analyzed. The mean age was 9.7 ± 0.66 years, with 48,2% female patients. The number of eyes in the LRLL arm is 714 and, in the control, arm is 656. LLRL showed better results in SER and AL mean change (OR = 0.58; 95% CI 0.33 to 0.83; p < 0.00001, and MD -0.33; 95% CI -0.52 to -0.13; p = 0.001, respectively), in comparison to the control group. There was no significant difference in adverse effects between groups (MD = 5.76; 95% CI 0.66 to 50.14; p = 0.11).
Conclusion
LLRL therapy is a non-invasive, effective, and safe short-term treatment option; however, long-term evaluation, particularly in comparison to other therapies, requires additional investigation.
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