Safety of repeated low-level red-light therapy for children with myopia
Zhu M, Liu Y, Fang D, Li M, Fu T, Yao K, Wang P, Sun X, Xiang Y
Photodiagnosis and photodynamic therapy · 22 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Natural Science Foundation of Hubei Province
- Subvenciones
- National Natural Science Foundation of China (82000893); Natural Science Foundation of Hubei Province (2021CFB342)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-05-08 · Photodiagnosis Photodyn Ther · vol. 47 · pág. 104198
- Editorial
- Elsevier BV
- Citado
- 29 citas · más que el 98% de estudios similares · 7.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Retinal Diseases and Treatments
- Palabras clave
- Light therapy, Red light, Medicine, Optometry, Internal medicine, Biology
- MeSH
- humans, myopia, tomography, optical coherence, electroretinography, contrast sensitivity, child, female, male, low-level light therapy
9 autores
- Mengxia Zhu🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Ying Liu🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Dengqin Fang🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Mu Li🇭🇰🇨🇳Union Hospital; Huazhong University of Science and Technology
- Ting Fu🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- KeJun Yao🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Ping Wang🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Xufang Sun🇨🇳Tongji Hospital; Huazhong University of Science and Technology
- Yan Xiang🇨🇳 · autor de correspondenciaTongji Hospital; Huazhong University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Backgroud
To investigate the safety of repetitive low-level red-light therapy (RLRLT) in children with myopia.
Methods
Children with myopia were assigned to the RLRL and control groups. Axial length (AL) and spherical equivalent refraction (SER) were followed up at 3-, 6-, and 12-month. To evaluate the safety of RLRLT, at 6 and 12 months in the RLRL group, multifocal electroretinography (mfERG) and contrast sensitivity were recorded. Furthermore, optical coherence tomography was used to measure the relative reflectance of the ellipsoid zone (rEZR), photoreceptor outer segment (rPOSR), and retinal pigment epithelium (rRPER).
Results
A total of 108 children completed the trial (55 in the RLRL group and 53 in the control group). After 3, 6, and 12 months, AL was shorter and SER less myopic in the RLRL group than in the control group. Regarding the safety of the RLRLT, the response density and amplitude of the P1 wave of the first ring of the mfERG increased significantly at 6 months (P = 0.001 and P = 0.017, respectively). At 6 and 12 months, contrast sensitivity at the high spatial frequency increased. Moreover, the rEZR increased significantly at 6 months (P = 0.029), the rPOSR increased significantly at 6 and 12 months (both P < 0.001), and the increase in rPOSR was greater with greater AL regression.
Conclusions
Based on retinal function and structure follow-up, RLRLT was safe within 12 months. However, rEZR and rPOSR increased, the effects of this phenomenon requires further observation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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