Financiado en parte por Natreon (United States), Natreon Inc.
Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial
Pandit S, Srivastav AK, Sur TK, Chaudhuri S, Wang Y, Biswas TK
Nutrients · 25 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Indian Council of Medical Research
- Empresa
- Natreon (United States)
- Empresa
- Natreon Inc.
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-04-26 · Nutrients · vol. 16 · número 9 · pág. 1293
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 45 citas · más que el 100% de estudios similares · 22.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Mindfulness and Compassion Interventions · Hallucinations in medical conditions
- Palabras clave
- Withania somnifera, Medicine, Placebo, Randomized controlled trial, Chronic stress, Phytotherapy, Internal medicine, Traditional medicine, Pathology
- MeSH
- pituitary-adrenal system, hypothalamo-hypophyseal system, humans, withania, plant leaves, plant roots, chronic disease, plant extracts, medicine, ayurvedic, phytotherapy, double-blind method, stress, psychological, adult, middle aged, female, male, young adult
6 autores
- Srikanta Pandit🇮🇳Government of West Bengal
- Amit Kumar Srivastav🇮🇳Government of West Bengal
- Tapas Kumar Sur🇮🇳Government of West Bengal
- Supriyo Chaudhuri🇮🇳Government of West Bengal
- Yan Wang🇺🇸University of California, Los Angeles
- Tuhin Kanti Biswas🇮🇳 · autor de correspondenciaGovernment of West Bengal
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Stress is a known causative factor in modulating cognitive health, which overall well-being and quality of life are dependent on. Long-term stress has been shown to disrupt the balance of the hypothalamic-pituitary-adrenal (HPA) axis. Adaptogens, such as Withania somnifera (ashwagandha), are commonly used in Ayurvedic medicine for stress relief and ameliorating HPA-axis dysfunction. The aim of this study was to support the role of a root and leaf water-extracted ashwagandha extract (WS) in stress reduction by confirming the lowest clinically validated dose for stress management (125 mg/day) in a dose-dependent clinical study in adults with self-reported high stress.
Methods
An 8-week, randomized, double-blinded, placebo-controlled study to compare the effects of three different WS extract doses (125, 250 and 500 mg) was performed. A total of 131 adults were enrolled, and 98 were included in the final analysis. Attenuation of chronic stress was measured using the 14-item Perceived Stress Scale (PSS) and biochemical-related stress parameters.
Results
We have shown that aqueous WS extract (roots and leaves) safely reduces mild to moderate chronic stress at doses of 125 mg, 250 mg, and 500 mg/day for 8 weeks.
Conclusions
Our findings demonstrate the stress-reduction capabilities of this well-characterized aqueous extract of WS (root and leaf) at the low dose of 125 mg/day, in a dose-dependent manner, via the modulation of the HPA axis.
Trial registration
This study was registered with the Clinical Trials Registry-India (CTRI) with the registration number: CTRI/2019/11/022100.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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