Synergistic impact of 25-hydroxyvitamin D concentrations and physical activity on delaying aging
Liu C, Hua L, Xin Z
Redox biology · 67 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-05-10 · Redox Biol · vol. 73 · pág. 103188
- Editorial
- Elsevier BV
- Citado
- 68 citas · más que el 100% de estudios similares · 19.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Vitamin D Research Studies · Health, Environment, Cognitive Aging · Nutritional Studies and Diet
- Palabras clave
- Vitamin D and neurology, Gerontology, Physical activity, Medicine, Endocrinology, Physical medicine and rehabilitation
- MeSH
- humans, vitamin d, exercise, nutrition surveys, aging, adult, aged, middle aged, female, male
3 autores
- Chang Liu🇨🇳Beijing Tongren Hospital; Capital Medical University
- Lin Hua🇨🇳 · autor de correspondenciaCapital Medical University
- Xin Zhong🇨🇳 · autor de correspondenciaBeijing Tongren Hospital; Capital Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Our study aims to examine the independent and combined associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations and physical activity (PA) status with phenotypic age (PhenoAge).
Method
The analysis included 18,738 participants from the NHANES 2007-2010 & 2015-2018. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated as the residuals from regressing PhenoAge on chronological age. Weighted multivariable logistic regression models were used to analysis the relationship between 25(OH)D and PA with PhenoAgeAccel. Population attributable fraction (PAF) was used to estimate the proportion of PhenoAgeAccel which could be avoided if exposure were eliminated.
Results
The multivariate-adjusted OR (95%CI) for PhenoAgeAccel with high 25(OH)D and adequate PA were 0.657 (0.549,0.787) (p < 0.001) for all, 0.663 (0.538,0.818) (p < 0.001) for participants whose age ≤65years old. Furthermore, there was multiplicative interaction between 25(OH)D and PA in age ≤65 years old group (0.729 (0.542,0.979), p = 0.036). High 25(OH)D level and adequate PA reduced the risk of PhenoAgeAccel by 14.3 % and 14.2 %, respectively. Notably, 30.7 % decrease was attributable to both high 25(OH)D level and engaging in adequate PA concurrently. Combining 25(OH)D above 80.4 nmol/l with PA decreased PhenoAge by 1.291 years (p < 0.001).
Conclusion
Higher 25(OH)D level was associated with lower risk of biological ageing. Combining 25(OH)D and PA demonstrated enhanced protective effects, especially in middle or young adults. These findings underscore the importance of outdoor PA in slowing down the aging process.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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