The association between ultra-processed food and common pregnancy adverse outcomes: a dose-response systematic review and meta-analysis
Talebi S, Mehrabani S, Ghoreishy SM, Wong A, Moghaddam A, Feyli PR, Amirian P, Zarpoosh M, Kermani MAH, Moradi S
BMC pregnancy and childbirth · 23 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-05-15 · BMC Pregnancy Childbirth · vol. 24 · número 1 · pág. 369
- Editorial
- BioMed Central
- Citado
- 29 citas · más que el 94% de estudios similares · 3.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 140 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Gestational Diabetes Research and Management · Nutritional Studies and Diet
- Palabras clave
- ultra-processed foods, gestational diabetes mellitus, preeclampsia, preterm birth, low birth weight, small for gestational age, dose-response relationship, maternal diet
- MeSH
- humans, pregnancy complications, diabetes, gestational, pre-eclampsia, premature birth, pregnancy outcome, pregnancy, food handling, infant, newborn, infant, low birth weight, infant, small for gestational age, female, fast foods, food, processed
10 autores
- Sepide Talebi🇮🇷Tehran University of Medical Sciences
- Sanaz Mehrabani🇮🇷Isfahan University of Medical Sciences
- Seyed Mojtaba Ghoreishy🇮🇷Iran University of Medical Sciences
- Alexei Wong🇺🇸Marymount University
- Aliasghar Moghaddam🇮🇷Razi University
- Peyman Rahimi-Feyli🇮🇷Razi University
- Parsa Amirian🇮🇷Kermanshah University of Medical Sciences
- Mahsa Zarpoosh🇮🇷Kermanshah University of Medical Sciences
- Mohammad Ali Hojjati Kermani🇮🇷Masih Daneshvari Hospital; Shahid Beheshti University of Medical Sciences
- Sajjad Moradi🇮🇷 · autor de correspondenciaMaragheh University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Given the increasing incidence of negative outcomes during pregnancy, our research team conducted a dose-response systematic review and meta-analysis to investigate the relationship between ultra-processed foods (UPFs) consumption and common adverse pregnancy outcomes including gestational diabetes mellitus (GDM), preeclampsia (PE), preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA) infants. UPFs are described as formulations of food substances often modified by chemical processes and then assembled into ready-to-consume hyper-palatable food and drink products using flavors, colors, emulsifiers, and other cosmetic additives. Examples include savory snacks, reconstituted meat products, frozen meals that have already been made, and soft drinks.
Methods
A comprehensive search was performed using the Scopus, PubMed, and Web of Science databases up to December 2023. We pooled relative risk (RR) and 95% confidence intervals (CI) using a random-effects model.
Results
Our analysis (encompassing 54 studies with 552,686 individuals) revealed a significant association between UPFs intake and increased risks of GDM (RR = 1.19; 95% CI: 1.10, 1.27; I2 = 77.5%; p 2 = 80.0%; p = 0.025; studies = 12; number of participants = 54,955), while no significant relationships were found for PTB, LBW and SGA infants. Importantly, a 100 g increment in UPFs intake was related to a 27% increase in GDM risk (RR = 1.27; 95% CI: 1.07, 1.51; I2 = 81.0%; p = 0.007; studies = 9; number of participants = 39,812). The non-linear dose-response analysis further indicated a positive, non-linear relationship between UPFs intake and GDM risk Pnonlinearity = 0.034, Pdose-response = 0.034), although no such relationship was observed for PE (Pnonlinearity = 0.696, Pdose-response = 0.812).
Conclusion
In summary, both prior to and during pregnancy, chronic and excessive intake of UPFs is associated with an increased risk of GDM and PE. However, further observational studies, particularly among diverse ethnic groups with precise UPFs consumption measurement tools, are imperative for a more comprehensive understanding.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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