The association of ultra-processed food intake with neurodegenerative disorders: a systematic review and dose-response meta-analysis of large-scale cohorts
Pourmotabbed A, Talebi S, Mehrabani S, Babaei A, Khosroshahi RA, Bagheri R, Wong A, Ghoreishy SM, Amirian P, Zarpoosh M, Hojjati Kermani MA, Moradi S
Nutritional neuroscience · 11 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2024-05-16 · Nutr Neurosci · vol. 28 · número 1 · págs. 73–86
- Editorial
- Taylor & Francis
- Citado
- 15 citas · más que el 83% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 101 trabajos
- Acceso
- De pago
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Nutritional Studies and Diet · Dementia and Cognitive Impairment Research
- Palabras clave
- ultra-processed foods, neurodegenerative diseases, multiple sclerosis, Parkinson's disease, Alzheimer's disease, dementia, cognitive impairment, dose-response relationship, nonlinear relationship, dietary intake, diet and brain health
- MeSH
- humans, parkinson disease, neurodegenerative diseases, diet, cohort studies, fast foods, food, processed
12 autores
- Ali Pourmotabbed🇮🇷Kermanshah University of Medical Sciences
- Sepide Talebi🇮🇷Tehran University of Medical Sciences
- Sanaz Mehrabani🇮🇷Isfahan University of Medical Sciences
- Atefeh Babaei🇮🇷Kermanshah University of Medical Sciences
- Reza Amiri Khosroshahi🇮🇷Tehran University of Medical Sciences
- Reza Bagheri🇮🇷University of Isfahan
- Alexei Wong🇺🇸Marymount University
- Seyed Mojtaba Ghoreishy🇮🇷Iran University of Medical Sciences
- Parsa Amirian🇮🇷Kermanshah University of Medical Sciences
- Mahsa Zarpoosh🇮🇷Kermanshah University of Medical Sciences
- Mohammad Ali Hojjati Kermani🇮🇷Masih Daneshvari Hospital; Shahid Beheshti University of Medical Sciences
- Sajjad Moradi🇮🇷 · autor de correspondenciaMaragheh University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Our systematic review and meta-analysis aimed to uncover the relationship between UPFs intake and neurodegenerative disorders, including multiple sclerosis (MS), Parkinson's disease (PD), Alzheimer's disease (AD), cognitive impairment, and dementia.
Setting
A systematic search was conducted using the Scopus, PubMed/MEDLINE, and ISI Web of Science databases without any limitation until June 24, 2023. Relative risk (RR) and 95% confidence interval (CI) were pooled by using a random-effects model, while validated methods examined quality and publication bias via Newcastle-Ottawa Scale, Egger's regression asymmetry, and Begg's rank correlation tests, respectively.
Results
Analysis from 28 studies indicated that a higher UPFs intake was significantly related to an enhanced risk of MS (RR = 1.15; 95% CI: 1.00, 1.33; I2 = 37.5%; p = 0.050; n = 14), PD (RR = 1.56; 95% CI: 1.21, 2.02; I2 = 64.1%; p = 0.001; n = 15), and cognitive impairment (RR = 1.17; 95% CI: 1.06, 1.30; I2 = 74.1%; p = 0.003; n = 17), although not AD or dementia. We observed that a 25 g increment in UPFs intake was related to a 4% higher risk of MS (RR = 1.04; 95% CI: 1.01, 1.06; I2 = 0.0%; p = 0.013; n = 7), but not PD. The non-linear dose-response relationship indicated a positive non-linear association between UPF intake and the risk of MS (Pnonlinearity = 0.031, Pdose-response = 0.002). This association was not observed for the risk of PD (Pnonlinearity = 0.431, Pdose-response = 0.231).
Conclusion
These findings indicate that persistent overconsumption of UPFs may have an adverse impact on neurodegenerative conditions, potentially leading to a decline in quality of life and reduced independence as individuals age.
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