The effects of dietary nitrate ingestion on physical performance tests in 50-65 years old postmenopausal women: A pilot randomized, double-blind, placebo-controlled, and crossover study
Benjamim CJR, Lopes da Silva LS, da Silva Gonçalves L, Tasinafo Júnior MF, Spellanzon B, Rebelo MA, Tanus-Santos JE, Bueno Júnior CR
Clinical nutrition (Edinburgh, Scotland) · 6 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Subvenciones
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (200595/2022\u20139)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-05-22 · Clin Nutr · vol. 43 · número 7 · págs. 1642–1646
- Editorial
- Elsevier BV
- Citado
- 9 citas · más que el 79% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 21 trabajos
- Acceso
- De pago
- Áreas de investigación
- Exercise and Physiological Responses · Cardiovascular and exercise physiology · Muscle metabolism and nutrition
- Palabras clave
- dietary nitrate, beetroot juice, postmenopausal women, physical performance, 6-minute walk test, grip strength, sit-to-stand, agility, dynamic balance, plasma nitrite, cardiorespiratory capacity
- MeSH
- humans, beta vulgaris, nitrates, hand strength, pilot projects, cross-over studies, double-blind method, postmenopause, dietary supplements, aged, middle aged, female, fruit and vegetable juices, physical functional performance
8 autores
- Cicero Jonas R. Benjamim🇧🇷 · autor de correspondenciaUniversidade de São Paulo
- Leonardo Santos Lopes da Silva🇧🇷Universidade de São Paulo
- Leonardo da Silva Gonçalves🇧🇷Universidade de São Paulo
- Márcio Fernando Tasinafo Júnior🇧🇷Universidade de São Paulo
- Bruno Spellanzon🇬🇧University of Bath
- Macário Arosti Rebelo🇧🇷Universidade Estadual de Campinas (UNICAMP)
- José Eduardo Tanus-Santos🇧🇷Universidade de São Paulo; Universidade Estadual de Campinas (UNICAMP)
- Carlos Roberto Bueno Júnior🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
The post-menopausal period represents a noteworthy stage in a woman's life characterized by hormonal shifts that can influence diverse biological processes encompassing energy metabolism and physical performance. NO3- effects on physical performance in 50-65 years old postmenopausal women after short-term supplementation remain unknown.
Methods
This is a randomized, double-blind, placebo-controlled, crossover study. After two sessions in non-consecutive days of familiarization tests, fifteen post-menopausal women aged between 50 and 65 were enrolled in this study. The trial consisted of two eight-day arms: a) NO3- -70 mL of beetroot juice (BRJ) with ˜400 mg of NO3-, and b) placebo (PLA) -70 mL of BRJ NO3- depleted. Both interventions were obtained from the same manufacturer's product, presenting the same organoleptic properties. After this period, five physical performance tests (handgrip strength, arm curl, sit-to-stand, agility and dynamic balance and 6-min walk test (6MWT)) were applied.
Results
Fourteen participants completed all experimental protocols, including a minimum seven-day washout period between protocols. NO2- plasma concentrations were consistently elevated in the NO3- condition at 0.41 (0.40) μM compared to the PLA at 0.18 (0.18) μM (p 3- condition (19.6 m [95%CI: 1.33 to 37.88]; p = 0.038), while the other physical performance tests did not show significant difference between conditions (p > 0.05).
Conclusions
Our findings suggest benefits in the physical performance of activities with longer durations, indicating that the adaptation caused by ingestion of NO3- may be related to the cardiorespiratory capacity.
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