Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies
Hajhashemy Z, Shirani F, Askari G
Nutrition reviews · 7 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Isfahan University of Medical Sciences
- Universidad u hospital
- Student Research Committee, Tabriz University of Medical Sciences
- Universidad u hospital
- Student Research Committee
- Universidad u hospital
- Isfahan University of Medical Sciences, Isfahan, Iran
- Subvenciones
- Isfahan University of Medical Sciences (140274)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2024-05-29 · Nutr Rev · vol. 83 · número 2 · págs. 217–229
- Editorial
- Oxford University Press
- Citado
- 10 citas · más que el 71% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments · Magnesium Alloys: Properties and Applications
- Palabras clave
- Meta-analysis, Medicine, Depression (economics), Physiology, Magnesium, Internal medicine, Endocrinology, Gerontology, Chemistry
- MeSH
- humans, magnesium, diet, depression, dose-response relationship, drug, adult
3 autores
- Zahra Hajhashemy🇮🇷Isfahan University of Medical Sciences
- Fatemeh Shirani🇮🇷Isfahan University of Medical Sciences
- Gholamreza Askari🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
The relation of magnesium (Mg) intake with depression was previously investigated by meta-analyses. However, due to limited data, a dose-response analysis was not performed.
Objective
Considering the recently published articles, a systematic review and dose-response meta-analysis was conducted to summarize the relation of dietary Mg intake with depression in adults.
Data sources
Medline (PubMed), ISI Web of Science, Scopus, and Google Scholar were comprehensively searched up to August 2023.
Data extraction
Observational studies that reported the relation of dietary Mg intake and depression in adults were included and their data were extracted.
Data analysis
A total of 63 214 participants from 10 cross-sectional and 3 cohort studies were included in the current study. Pooling 15 effect sizes from 12 studies (including 50 275 participants) revealed that individuals with the highest Mg intake had a 34% lower risk of depression, compared with those with the lowest Mg intake (RR: 0.66; 95% CI: 0.57, 0.78). Moreover, the linear dose-response analysis revealed that each 100-mg/d increment in Mg intake was associated with a 7% reduced risk of depression (RR: 0.93; 95% CI: 0.90, 0.96). Additionally, based on nonlinear dose-response analysis, increasing Mg intake from 170 to 370 mg/d was associated with a reduced risk of depression. Analyses were also conducted on 9 studies (49 558 participants) with representative populations, and similar results were found in the meta-analysis (RR: 0.71; 95% CI: 0.61, 0.83) and linear (RR: 0.93; 95% CI: 0.90, 0.96) and nonlinear dose-response analysis.
Conclusion
The current study shows an inverse dose-dependent association between dietary Mg intakes and risk of depression in both a general and representative population of adults in a dose-response manner.
Systematic review registration
PROSPERO registration no. CRD42024506570.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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