Financiado en parte por California Walnut Commission, Nutricia Research Foundation
Effects of walnut consumption for 2 years on older adults' bone health in the Walnuts and Healthy Aging (WAHA) trial
Oliver-Pons C, Sala-Vila A, Cofán M, Serra-Mir M, Roth I, Valls-Pedret C, Domènech M, Ortega E, Rajaram S, Sabaté J, Ros E, Chiva-Blanch G
Journal of the American Geriatrics Society · 5 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Loma Linda University
- Grupo de la industria
- California Walnut Commission
- Empresa
- Nutricia Research Foundation
- Subvenciones
- California Walnut Commission (CWC2017); Nutricia Research Foundation (2022-25)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2024-05-31 · J Am Geriatr Soc · vol. 72 · número 8 · págs. 2471–2482
- Editorial
- Wiley
- Citado
- 6 citas · más que el 87% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 37 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Bone health and osteoporosis research · Nuts composition and effects · Bone Metabolism and Diseases
- Palabras clave
- walnut consumption, bone mineral density, bone health, older adults, bone turnover markers, alpha-linolenic acid, polyphenols, dietary intervention, osteoporosis, healthy aging
- MeSH
- humans, juglans, nuts, osteoporosis, absorptiometry, photon, diet, bone remodeling, bone density, aged, middle aged, female, male, biomarkers, healthy aging
12 autores
- Carla Oliver‐Pons🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Aleix Sala‐Vila🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Hospital del Mar Research Institute
- Montserrat Cofán🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Mercè Serra‐Mir🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Irene Roth🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Cinta Valls‐Pedret🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Mónica Doménech🇪🇸Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Emilio Ortega🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Sujatha Rajaram🇺🇸Loma Linda University
- Joan Sabaté🇺🇸Loma Linda University
- Emilio Ros🇪🇸 · autor de correspondenciaInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
- Gemma Chiva‐Blanch🇪🇸 · autor de correspondenciaUniversitat Oberta de Catalunya; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red; Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Nutritional strategies to maintain bone health in aging individuals are of great interest. Given the beneficial nutrient composition of walnuts, rich in alpha-linolenic (the vegetable n-3 fatty acid) and polyphenols, their regular consumption might be a dietary option to reduce age-related bone loss. We determined whether daily walnut consumption improves bone mineral density (BMD) and circulating biomarkers of bone turnover.
Methods
The Walnuts and Healthy Aging study (WAHA) is a two-center, parallel, randomized controlled trial evaluating the effect of a diet enriched with walnuts at ≈15% energy compared with a control diet for 2 years on age-related health outcomes in healthy men and women aged 63-79 years. Changes in BMD were a prespecified secondary outcome only at the Barcelona node of the trial, where 352 participants were randomized. Retention rate was 92.6%. Primary endpoints were 2-year changes in BMD at the spine and the nondominant femoral neck, determined by dual-energy X-ray absorptiometry (DXA). Secondary endpoints were 2-year changes in bone turnover biomarkers (adrenocorticotropic hormone, Dickkopf WNT signaling pathway inhibitor-1, osteoprotegerin, osteocalcin, osteopontin, sclerostin, parathyroid hormone, and fibroblast growth factor-23), which were quantified in 211 randomly selected participants.
Results
The walnut diet versus the control diet had no effect on 2-year changes in BMD at the spine (0.15% vs. 0.35%, p = 0.632) and femoral neck (-0.90% vs. -0.70%, p = 0.653), or on bone turnover biomarkers. Results were similar in participants treated or not with bone resorption inhibitors or those with or without osteoporosis/osteopenia at inclusion.
Conclusions
Compared with the usual diet, a diet enriched with walnuts at 15% of energy for 2 years failed to improve BMD or circulating markers of bone metabolism in healthy older people.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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