Financiado en parte por Eli Lilly and Company
Protective effects of sulforaphane against toxic substances and contaminants: A systematic review
Cascajosa-Lira A, Prieto AI, Pichardo S, Jos A, Cameán AM
Phytomedicine : international journal of phytotherapy and phytopharmacology · 16 citas
Etiquetas de revisión
Financiado por la industriaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Eli Lilly and Company
- Gobierno
- Junta de Andalucía
- Subvenciones
- Junta de Andalucía (P18-TP-2147)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2024-05-19 · Phytomedicine · vol. 130 · pág. 155731
- Editorial
- Elsevier BV
- Citado
- 31 citas · más que el 85% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 112 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Curcumin's Biomedical Applications · Retinoids in leukemia and cellular processes
- Palabras clave
- Sulforaphane, Environmental chemistry, Contamination, Chemistry, Toxicology, Biology, Biochemistry, Ecology
- MeSH
- animals, humans, brassica, isothiocyanates, sulfoxides, protective agents, oxidative stress, nf-e2-related factor 2
5 autores
- Antonio Cascajosa-Lira🇪🇸Universidad de Sevilla
- Ana Isabel Prieto🇪🇸 · autor de correspondenciaUniversidad de Sevilla
- Silvia Pichardo🇪🇸Universidad de Sevilla
- Angeles M. Jos🇪🇸Universidad de Sevilla
- Ana Maria Cameán🇪🇸Universidad de Sevilla
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Sulforaphane (SFN) is a dietary isothiocyanate, derived from glucoraphanin, present in cruciferous vegetables belonging to the Brassica genus. It is a biologically active phytochemical that acts as a nuclear factor erythroid 2-related factor 2 (Nrf2) inducer. Thus, it has been reported to have multiple protective functions including anticancer responses and protection against a toxic agent's action.
Purpose
The present work systematically reviewed and synthesised the protective properties of sulforaphane against a toxic agent. This review reveals the mechanism of the action of SFN in each organ or system.
Methods
The PRISMA guideline was followed in this sequence: researched literature, organised retrieved documents, abstracted relevant information, assessed study quality and bias, synthesised data, and prepared a comprehensive report. Searches were conducted on Science Direct and PubMed using the keywords "Sulforaphane" AND ("protective effects" OR "protection against").
Results
Reports showed that liver and the nervous system are the target organs on which attention was focused, and this might be due to the key role of oxidative stress in liver and neurodegenerative diseases. However, protective activities have also been demonstrated in the lungs, heart, immune system, kidneys, and endocrine system. SFN exerts its protective effects by activating the Nrf2 pathway, which enhances antioxidant defenses and reduces oxidative stress. It also suppresses inflammation by decreasing interleukin production. Moreover, SFN inhibits apoptosis by preventing caspase 3 cleavage and increasing Bcl2 levels. Overall, SFN demonstrates multifaceted mechanisms to counteract the adverse effects of toxic agents.
Conclusion
SFN has potential clinical applications as a chemoprotective agent. Nevertheless, more studies are necessary to set the safe doses of SFN in humans.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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