Financiado en parte por Lantmännens Forskningsstiftelse, Valio
Association between whole-grain consumption, tryptophan metabolism and psychological distress: a secondary analysis of a randomised controlled trial
Liikonen V, Näätänen M, Kårlund A, Hanhineva K, Karhunen L, Kolehmainen M
The British journal of nutrition · 1 cita
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Lantmännens Forskningsstiftelse
- Gobierno
- European Commission
- Gobierno
- Tekes
- Organización sin fines de lucro
- Jane ja Aatos Erkon Säätiö
- Organización sin fines de lucro
- Juho Vainion Säätiö
- Empresa
- Valio
- Organización sin fines de lucro
- OLVI-Säätiö
- Universidad u hospital
- Biocenter Finland
- Subvenciones
- European Commission (874739); Jane ja Aatos Erkon Säätiö (321716); European Commission (334814); European Commission (HORIZON2020); Tekes (40100/07); Jane ja Aatos Erkon Säätiö (334814); Tekes (1104/10); European Commission (321716)
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-06-03 · Br J Nutr · vol. 132 · número 3 · págs. 330–340
- Editorial
- Cambridge University Press
- Citado
- 3 citas · más que el 46% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Tryptophan and brain disorders · Nutritional Studies and Diet · Food composition and properties
- Palabras clave
- whole grain intake, tryptophan metabolism, psychological distress, weight loss, weight maintenance, serotonin, tryptophan metabolites, gut microbiota, dietary fiber, overweight adults
- MeSH
- humans, weight loss, serotonin, propionates, indoles, tryptophan, diet, stress, psychological, adult, middle aged, female, male, whole grains, psychological distress
6 autores
- Vilma Liikonen🇫🇮 · autor de correspondenciaUniversity of Eastern Finland
- Mari Näätänen🇫🇮University of Eastern Finland
- Anna Kårlund🇫🇮University of Turku; University of Eastern Finland
- Kati Hanhineva🇫🇮University of Turku; University of Eastern Finland
- Leila J. Karhunen🇫🇮University of Eastern Finland
- Marjukka Kolehmainen🇫🇮University of Eastern Finland
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study aimed to investigate whether psychological distress, whole-grain consumption and tryptophan metabolism are associated with participants undergoing weight management intervention. Seventy-nine women and men (mean age 49·7 (sd 9·0) years; BMI 34·2(sd 2·5) kg/m2) participated in a 7-week weight-loss (WL) period and in a 24-week weight maintenance (WM) intervention period. Whole-grain consumption was measured using 4 d food diaries. Psychological distress was assessed with the General Health Questionnaire-12 (GHQ), and participants were divided into three GHQ groups based on the GHQ scores before WL. Tryptophan metabolites were determined from the participants' fasting plasma using liquid chromatography-MS. GHQ scores were not associated with the whole-grain consumption. A positive association was observed between the whole-grain consumption and indole propionic acid (IPA) during the WM (P = 0·033). Serotonin levels were higher after the WL in the lowest GHQ tertile (P = 0·033), while the level at the end of the WM was higher compared with other timepoints in the highest GHQ tertile (P = 0·015 and P = 0·001). This difference between groups was not statistically significant. Furthermore, levels of several tryptophan metabolites changed within the groups during the study. Tryptophan metabolism changed during the study in the whole study group, independently from the level of psychological distress. The association between whole-grain consumption and IPA is possibly explained by the effects of dietary fibre on gut microbiota. This broadens the understanding of the pathways behind the health benefits associated with the intake of whole grains.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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