Repeated Low-Level Red Light Therapy for Myopia Control in High Myopia Children and Adolescents: A Randomized Clinical Trial
Xu Y, Cui L, Kong M, Li Q, Feng X, Feng K, Zhu H, Cui H, Shi C, Zhang J, Zou H
Ophthalmology · 66 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Shanghai Municipal Health and Family Planning Commission
Según 1 financiador declarado.
Publicación
- Publicado
- 2024-06-06 · Ophthalmology · vol. 131 · número 11 · págs. 1314–1323
- Editorial
- Elsevier BV
- Citado
- 77 citas · más que el 100% de estudios similares · 20.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Corneal surgery and disorders · Retinopathy of Prematurity Studies
- Palabras clave
- Medicine, Optometry
- MeSH
- humans, myopia, degenerative, refraction, ocular, treatment outcome, follow-up studies, single-blind method, eyeglasses, visual acuity, adolescent, child, female, male, low-level light therapy
11 autores
- Yan Xu🇨🇳Tongji University; Shanghai Eye Disease Prevention & Treatment Center
- Lipu Cui🇨🇳Shanghai Jiao Tong University; Shanghai First People's Hospital
- Miao Kong🇨🇳Shanxi Eye Hospital
- Qian Li🇨🇳Shanghai East Hospital
- Xueliang Feng🇨🇳Shanxi Eye Hospital
- K D Feng🇨🇳Soochow University
- Huang Zhu🇨🇳Shanghai Jiao Tong University; XinHua Hospital
- Hongping Cui🇨🇳Shanghai East Hospital
- Caiping Shi🇨🇳Children's Hospital of Zhejiang University
- Jian Zhang🇨🇳 · autor de correspondenciaSun Yat-sen University; Key Laboratory of Guangdong Province; Guangdong Provincial Center for Disease Control and Prevention
- Haidong Zou🇨🇳 · autor de correspondenciaTongji University; Shanghai Jiao Tong University; Shanghai Eye Disease Prevention & Treatment Center; Shanghai First People's Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To assess the effectiveness and safety of repeated low-level red light (RLRL), which is a newly available treatment for myopia control in children and adolescents with high myopia.
Design
Multicenter, randomized, parallel-group, single-blind clinical trial (randomized controlled trial; NCT05184621).
Participants
Between February 2021 and April 2022, 192 children aged 6 to 16 years were enrolled. Each child had at least 1 eye with myopia of cycloplegic spherical equivalent refraction (SER) at least -4.0 diopters (D), astigmatism of ≤2.0 D, anisometropia of ≤3.0 D, and best-corrected visual acuity (BCVA) of 0.2 logarithm of the minimum angle of resolution or better. Follow-up was completed by April 2023.
Methods
Participants were randomly assigned at a 1:1 ratio to intervention (RLRL treatment plus single-vision spectacles) or control (single-vision spectacles) groups. The RLRL treatment was administered for 3 minutes per session, twice daily with a minimum interval of 4 hours, 7 days per week.
Mean outcome measures
The primary outcome and key secondary outcome were changes in axial length (AL) and cycloplegic SER measured at baseline and the 12-month follow-up visit. Participants who had at least 1 postrandomization follow-up visit were analyzed for treatment efficacy.
Results
Among 192 randomized participants, 188 (97.91%) were included in the analyses (96 in the RLRL group and 92 in the control group). After 12 months, the adjusted mean change in AL was -0.06 mm (95% confidence interval [CI], -0.10 to -0.02 mm) and 0.34 mm (95% CI, 0.30 to 0.39 mm) in the intervention and control groups, respectively. A total of 48 participants (53.3%) in the intervention group were still experiencing axial shortening >0.05 mm at the 12-month follow-up. The mean SER change after 12 months was 0.11 D (95% CI, 0.02to 0.19 D) and -0.75 D (95% CI, -0.88 to -0.62 D) in the intervention and control groups, respectively.
Conclusions
Repeated low-level red light demonstrates stronger treatment efficacy among those with high myopia, with 53.3% experiencing substantial axial shortening. Repeated low-level red light provides an excellent solution for the management of high myopia progression, a significant challenge in ophthalmology practice.
Financial disclosure(s)
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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