Photobiomodulation in the aging brain: a systematic review from animal models to humans
Rodríguez-Fernández L, Zorzo C, Arias JL
GeroScience · 20 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universidad de Oviedo
- Gobierno
- Ministry of Economy
- Gobierno
- Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología
- Gobierno
- Ministry of Economy and Industry
- Gobierno
- Foundation for scientific and technical research FICYT
- Subvenciones
- Ministry of Economy (PID2020-117259RB-I00)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-06-11 · Geroscience · vol. 46 · número 6 · págs. 6583–6623
- Editorial
- Springer International Publishing
- Citado
- 31 citas · más que el 94% de estudios similares · 2.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 121 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Laser Applications in Dentistry and Medicine · Photodynamic Therapy Research Studies · Biofield Effects and Biophysics
- Palabras clave
- low-level laser therapy, brain aging, age-related cognitive decline, Alzheimer's disease, mild cognitive impairment, Parkinson's disease, memory, mitochondrial function, neuroprotection, anti-inflammatory activity, non-pharmacological treatment, treatment protocols
- MeSH
- brain, animals, humans, disease models, animal, cognition, aging, low-level light therapy, cognitive dysfunction
3 autores
- Lucía Rodríguez‐Fernández🇪🇸Universidad de Oviedo
- Candela Zorzo · autor de correspondencia
- Jorge Luis Arias🇪🇸Instituto de Investigación Sanitaria del Principado de Asturias
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) is a non-pharmacological therapy that shows promising results in the treatment or prevention of age-related cognitive impairments. The aim of this review is to compile the preclinical and clinical evidence of the effect of PBM during aging in healthy and pathological conditions, including behavioral analysis and neuropsychological assessment, as well as brain-related modifications. 37 studies were identified by searching in PubMed, Scopus, and PsycInfo databases. Most studies use wavelengths of 800, 810, or 1064 nm but intensity and days of application were highly variable. In animal studies, it has been shown improvements in spatial memory, episodic-like memory, social memory, while different results have been found in recognition memory. Locomotor activity improved in Parkinson disease models. In healthy aged humans, it has been outlined improvements in working memory, cognitive inhibition, and lexical/semantic access, while general cognition was mainly enhanced on Alzheimer disease or mild cognitive impairment. Anxiety assessment is scarce and shows mixed results. As for brain activity, results outline promising effects of PBM in reversing metabolic alterations and enhancing mitochondrial function, as evidenced by restored CCO activity and ATP levels. Additionally, PBM demonstrated neuroprotective, anti-inflammatory, immunomodulatory and hemodynamic effects. The findings suggest that PBM holds promise as a non-invasive intervention for enhancing cognitive function, and in the modulation of brain functional reorganization. It is necessary to develop standardized protocols for the correct, beneficial, and homogeneous use of PBM.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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