Exploring the relationship between creatine supplementation and renal function: insights from Mendelian randomization analysis
Zhou B, Hong M, Jin L, Ling K
Renal failure · 7 citas
Cómo se estudió
- Diseño
- Estudio transversal (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Gujarat Council on Science and Technology
- Gobierno
- Zhejiang Traditional Chinese Medicine Administration
- Gobierno
- Medical Science and Technology Project of Zhejiang Provincial Health Commission
- Subvenciones
- Zhejiang Traditional Chinese Medicine Administration (2024ZL1058)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-06-14 · Ren Fail · vol. 46 · número 2 · pág. 2364762
- Editorial
- Taylor & Francis
- Citado
- 10 citas · más que el 85% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Muscle metabolism and nutrition · Chronic Kidney Disease and Diabetes · Genetics and Physical Performance
- Palabras clave
- creatine supplementation, renal function, fitness enthusiasts, athletic performance, dietary supplementation, Mendelian randomization
- MeSH
- kidney, humans, creatine, reproducibility of results, dietary supplements, adult, middle aged, female, male, young adult, mendelian randomization analysis, surveys and questionnaires
4 autores
- Bing Zhou
- Minping Hong
- Liqin Jin🇨🇳Jiaxing University
- Keng Ling🇨🇳 · autor de correspondenciaJiaxing University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Creatine supplementation is ubiquitously consumed by fitness enthusiasts due to its perceived advantages in enhancing athletic performance. Although there is an increasing concern within this demographic regarding its possible impact on renal function, there is still a lack of rigorous scientific investigations into this alleged association.
Methods
Data were collected through an online survey on the participants' demographics, creatine usage and concerns related to renal function. The reliability and validity of the survey were assessed using SPSS software. A total of 1129 participants responded to the survey, and chi-square tests were utilized for data analysis. To explore the potential association between creatine levels (as the exposure) and renal function (as the outcome), we utilized open-access genetic databases, and Mendelian randomization (MR) techniques were used to confirm this correlation.
Results
Chi-square analysis revealed no significant association between creatine usage and renal function among the participants. Our MR analysis further supported this finding, demonstrating no significant association between creatine levels and six indicators assessing renal function (IVW, all with p values exceeding 0.05). Similar p values were consistently observed across other MR methods, confirming the absence of a statistical correlation.
Conclusions
This MR study offers compelling evidence indicating that creatine levels are not statistically associated with renal function, suggesting the potential to alleviate concerns within the fitness community and emphasizing the significance of evidence-based decision-making when considering nutritional supplementation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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