Effects of DASH diet with or without time-restricted eating in the management of stage 1 primary hypertension: a randomized controlled trial
Zhou X, Lin X, Yu J, Yang Y, Muzammel H, Amissi S, Schini-Kerth VB, Lei X, Jose PA, Yang J, Shi D
Nutrition journal · 22 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Chongqing Medical University
- Gobierno
- Scientific Research Innovation Project for Postgraduate in Chongqing
- Universidad u hospital
- Program of Chongqing Medical University for Youth Innovation in Future Medicine
- Subvenciones
- National Natural Science Foundation of China (8210120502); National Natural Science Foundation of China (82100459); Chongqing Medical University (W0085)
Según 4 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-06-17 · Nutr J · vol. 23 · número 1 · pág. 65
- Editorial
- BioMed Central
- Citado
- 26 citas · más que el 97% de estudios similares · 6.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Enhanced Recovery After Surgery · Nutritional Studies and Diet
- Palabras clave
- Dash, DASH diet, Medicine, Blood pressure, Excretion, Randomized controlled trial, Internal medicine, Physical therapy
- MeSH
- humans, hypertension, treatment outcome, fasting, blood pressure, adult, middle aged, female, male, dietary approaches to stop hypertension
11 autores
- Xiaoxin Zhou🇫🇷🇨🇳Université de Strasbourg; Chongqing Medical University
- Xiaoqian Lin🇨🇳Chongqing Medical University
- Jing Yu🇨🇳Chongqing Public Health Medical Center; Chongqing Medical University
- Yi Yang🇨🇳Chongqing Medical University
- Hira Muzammel🇫🇷Université de Strasbourg
- Said Amissi🇫🇷Université de Strasbourg
- Valérie B. Schini‐Kerth🇫🇷Université de Strasbourg
- Xun Lei🇨🇳Chongqing Medical University
- Pedro A. José🇺🇸George Washington University
- Jian Yang🇨🇳 · autor de correspondenciaArmy Medical University; Chongqing Medical University
- Dan Shi🇨🇳 · autor de correspondenciaChongqing Public Health Medical Center; Chongqing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Time-restricted eating (TRE), a popular form of intermittent fasting, has shown benefits for improving metabolic diseases and cardiometabolic health. However, the effect of TRE in the regulation of blood pressure in primary hypertension remains unclear.
Methods
A 6-week randomized controlled trial was conducted, in which a total of 74 stage 1 primary hypertensive patients without high-risk were randomly assigned to Dietary Approaches to Stop Hypertension (DASH) group (n = 37) or DASH + TRE group (n = 37). Participants in the DASH + TRE group were instructed to consume their food within an 8-h window. Scientific research platform in We Chat application was used to track participants. The primary outcome was blood pressure. The secondary outcomes included body composition, cardiometabolic risk factors, inflammation-related parameters, urinary Na+ excretion, other clinical variables and safety outcomes.
Results
The reduction of systolic blood pressure and diastolic blood pressure were 5.595 ± 4.072 and 5.351 ± 5.643 mm Hg in the DASH group and 8.459 ± 4.260 and 9.459 ± 4.375 mm Hg in the DASH + TRE group. DASH + TRE group improved blood pressure diurnal rhythm. Subjects in DASH + TRE group had decreased extracellular water and increased urinary Na+ excretion. Furthermore, the decrease in blood pressure was associated with a reduction of extracellular water or increase in urinary Na+ excretion. In addition, safety outcomes such as nighttime hunger were also reported.
Conclusion
Our study demonstrated that 8-h TRE + DASH diet caused a greater decrease in blood pressure in stage 1 primary hypertensive patients than DASH diet. This study may provide novel insights into the benefits of lifestyle modification in the treatment of primary hypertension.
Trial registration
https://www.chictr.org.cn/ (ChiCTR2300069393, registered on March 15, 2023).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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