Effect of reducing saturated fat intake on cardiovascular disease in adults: an umbrella review
Aramburu A, Dolores-Maldonado G, Curi-Quinto K, Cueva K, Alvarado-Gamarra G, Alcalá-Marcos K, Celis CR, Lanata CF
Frontiers in public health · 13 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2024-06-03 · Front Public Health · vol. 12 · pág. 1396576
- Editorial
- Frontiers Media
- Citado
- 24 citas · más que el 99% de estudios similares · 9.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health
- Palabras clave
- saturated fat intake, dietary fat reduction, cardiovascular disease, cardiovascular mortality, all-cause mortality, coronary heart disease mortality, breast cancer mortality, dietary intervention, adults
- MeSH
- humans, cardiovascular diseases, dietary fats, fatty acids, adult, randomized controlled trials as topic
8 autores
- Adolfo Aramburú🇵🇪 · autor de correspondenciaPeruvian University of Applied Sciences; Instituto de Investigación Nutricional
- Gandy Kerlin Dolores-Maldonado🇵🇪Instituto de Investigación Nutricional
- Katherine Curi-Quinto🇵🇪Instituto de Investigación Nutricional
- Karen Cueva Rodríguez🇵🇪Instituto de Investigación Nutricional
- Giancarlo Alvarado‐Gamarra🇵🇪 · autor de correspondenciaInstituto de Investigación Nutricional
- Katherine M. Alcalá-Marcos
- Carlos R. Celis🇵🇪Instituto de Investigación Nutricional
- Claudio Franco Lanata🇺🇸🇵🇪Vanderbilt University; Instituto de Investigación Nutricional
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Our objective was to explore the effect of the reduction of saturated fat (SAF) intake on cardiovascular disease, mortality and other health-related outcomes in adults.
Methods
We conducted an umbrella review, searching Medline, Scopus, EMBASE, Cochrane Library, and LILACS databases for systematic reviews from December 1, 2012, to December 1, 2022. We have included meta-analyses of randomized controlled trials (RCTs) and cohort studies. We extracted effect sizes (95%CI), heterogeneity (I 2), and evidence quality rating based on the population, intervention, comparator, and outcomes.
Results
21 meta-analyses were included (three were from RCTs, and 18 were from cohort studies). Among meta-analyses of RCTs, 15 of the 45 associations were significant. The effect of reduction in SAF intake on combined cardiovascular events (RR 0.79, 95%CI 0.66-0.93) was graded as having moderate certainty of evidence. We found no effect on all-cause mortality, cardiovascular mortality, cancer deaths, and other cardiovascular events. Among meta-analyses of cohort studies, five of the 19 associations were significant. There was an increase in coronary heart disease mortality (HR 1.10, 95% CI 1.01-1.21) and breast cancer mortality (HR 1.51, 95% CI 1.09-2.09) in participants with higher SFA intake compared to reduced SFA. We found no effect on all-cause mortality, cardiovascular mortality, and other cardiovascular events.
Conclusion
This umbrella review found the reduction in SAF intake probably reduces cardiovascular events and other health outcomes. However, it has little or no effect on cardiovascular mortality and mortality from other causes. More high-quality clinical trials with long-term follow-up are needed.Systematic review registration: CRD42022380859.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.